Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes.

Cell reports | 2018

Non-retroviral integrated RNA viral sequences (NIRVs) potentially encoding ∼280 amino acid homologs to filovirus VP35 proteins are present across the Myotis genus of bats. These are estimated to have been maintained for ∼18 million years, indicating their co-option. To address the reasons for co-option, 16 Myotis VP35s were characterized in comparison to VP35s from the extant filoviruses Ebola virus and Marburg virus, in which VP35s play critical roles in immune evasion and RNA synthesis. The Myotis VP35s demonstrated a conserved suppression of innate immune signaling, albeit with reduced potency, in either human or Myotis cells. Their attenuation reflects a lack of dsRNA binding that in the filoviral VP35s correlates with potent suppression of interferon responses. Despite divergent function, evolution has preserved in Myotis the structure of the filoviral VP35s, indicating that this structure is critical for co-opted function, possibly as a regulator of innate immune signaling.

Pubmed ID: 30044983 RIS Download

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Anti-HA antibody produced in rabbit (antibody)

RRID:AB_260070

This polyclonal antibody targets HA antibody produced in rabbit

View all literature mentions

Monoclonal ANTI-FLAG® M2 antibody (antibody)

RRID:AB_262044

This monoclonal antibody targets FLAG

View all literature mentions

PKR (phospho T446) antibody [E120] (antibody)

RRID:AB_777310

This monoclonal antibody targets PKR (phospho T446) antibody [E120]

View all literature mentions

Anti-FLAG® M2 Magnetic Beads antibody (antibody)

RRID:AB_2637089

This monoclonal antibody targets FLAG

View all literature mentions

Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb antibody (antibody)

RRID:AB_823547

This monoclonal antibody targets Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb

View all literature mentions

Flag antibody (antibody)

RRID:AB_439687

This polyclonal antibody targets 8 amino acid sequence (C-asp-tyr-lys-asp-asp-asp-asp-lys-N)

View all literature mentions