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Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their transfer into naive recipient mice. Following challenge infection, many memory cells differentiated into IgM-producing plasmablasts. Other donor B cells entered germinal centers, downregulated CD11c, underwent class switch recombination, and became switched memory cells. Yet other donor cells were maintained as IgM memory cells, and these IgM memory cells retained their multi-lineage potential following serial transfer. These findings were corroborated at the molecular level using immune repertoire analyses. Thus, IgM memory cells can differentiate into all effector B cell lineages and undergo self-renewal, properties that are characteristic of stem cells. We propose that these memory cells exist to provide long-term multi-functional immunity and act primarily to maintain the production of protective antibodies.
Pubmed ID: 30044980 RIS Download
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View all literature mentionsThis monoclonal targets CD138 (Syndecan-1)
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD73
View all literature mentionsThis monoclonal targets CD183
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD138
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