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Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects against fungal and bacterial infections. Fibrilization pathways mediate Aβ antimicrobial activities. Thus, infection can seed and dramatically accelerate β-amyloid deposition. Here, we show Aβ oligomers bind herpesvirus surface glycoproteins, accelerating β-amyloid deposition and leading to protective viral entrapment activity in 5XFAD mouse and 3D human neural cell culture infection models against neurotropic herpes simplex virus 1 (HSV1) and human herpesvirus 6A and B. Herpesviridae are linked to AD, but it has been unclear how viruses may induce β-amyloidosis in brain. These data support the notion that Aβ might play a protective role in CNS innate immunity, and suggest an AD etiological mechanism in which herpesviridae infection may directly promote Aβ amyloidosis.
Pubmed ID: 30001512 RIS Download
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This monoclonal targets HSV1 gH antibody [BBH1]
View all literature mentionsThis monoclonal targets HSV1 gG Envelope Protein
View all literature mentionsThis monoclonal targets HSV1 gE Envelope Protein
View all literature mentionsThis monoclonal targets Herpes Simplex Virus Type 1/2 gD
View all literature mentionsThis monoclonal targets HSV Type 1 gC
View all literature mentionsThis monoclonal targets Herpes Simplex Virus Type 1/2 gB
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets ?-Amyloid, 1-16
View all literature mentionsThis monoclonal targets beta-Amyloid 17-24
View all literature mentionsMus musculus with name B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax from MMRRC.
View all literature mentionsCell line Vero is a Spontaneously immortalized cell line with a species of origin Chlorocebus sabaeus
View all literature mentionsCell line H4 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line CHON-001 is a Telomerase immortalized cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax from MMRRC.
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