Atoh1-null mice die at birth from respiratory failure, but the precise cause has remained elusive. Loss of Atoh1 from various components of the respiratory circuitry (e.g. the retrotrapezoid nucleus (RTN)) has so far produced at most 50% neonatal lethality. To identify other Atoh1-lineage neurons that contribute to postnatal survival, we examined parabrachial complex neurons derived from the rostral rhombic lip (rRL) and found that they are activated during respiratory chemochallenges. Atoh1-deletion from the rRL does not affect survival, but causes apneas and respiratory depression during hypoxia, likely due to loss of projections to the preBötzinger Complex and RTN. Atoh1 thus promotes the development of the neural circuits governing hypoxic (rRL) and hypercapnic (RTN) chemoresponses, and combined loss of Atoh1 from these regions causes fully penetrant neonatal lethality. This work underscores the importance of modulating respiratory rhythms in response to chemosensory information during early postnatal life.
Pubmed ID: 29972353 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Seattle based independent, nonprofit medical research organization dedicated to accelerating the understanding of how human brain works. Provides free data and tools to researchers and educators and variety of unique online public resources for exploring the nervous system. Integrates gene expression data and neuroanatomy, along with data search and viewing tools, these resources are openly accessible via the Allen Brain Atlas data portal. Provides Allen Mouse Brain, Allen Spinal Cord Atlas, Allen Developing Mouse Brain Atlas, Allen Human Brain Atlas,Allen Mouse Brain Connectivity Atlas, Allen Cell Type Database, The Ivy Glioblastoma Atlas Project (Ivy GAP), The BrainSpan Atlas of the Developing Human Brain.
View all literature mentionsAn Antibody supplier and subset of ThermoFisher Scientific which provides fluorescence reagents for various experiments and methods.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets FOS
View all literature mentionsThis polyclonal targets NK-1 Receptor
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Calcitonin Gene Related Peptide antibody produced in rabbit
View all literature mentionsThis monoclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentionsMus musculus with name B6.129-Tg(Pcp2-cre)2Mpin/J from IMSR.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsMus musculus with name B6(Cg)-Tg(Phox2b-cre)3Jke/J from IMSR.
View all literature mentionsMus musculus with name B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm1Lowl/J from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsMus musculus with name B6.129S7-Atoh1tm2Hzo/J from IMSR.
View all literature mentionsMus musculus with name FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ.-EGFP)Glh/J from IMSR.
View all literature mentionsMus musculus with name STOCK En1tm2(cre)Wrst/J from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentionsThis monoclonal targets Tyrosine Hydroxylase
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Calcitonin Gene Related Peptide antibody produced in rabbit
View all literature mentionsThis polyclonal targets NK-1 Receptor
View all literature mentionsThis polyclonal targets FOS
View all literature mentionsMus musculus with name B6.129S7-Atoh1tm2Hzo/J from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted, Transgenic This is a legacy resource.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsAllele Detail: Targeted, Transgenic This is a legacy resource.
View all literature mentionsMus musculus with name B6(Cg)-Tg(Phox2b-cre)3Jke/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm1Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.129-Tg(Pcp2-cre)2Mpin/J from IMSR.
View all literature mentionsMus musculus with name FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ.-EGFP)Glh/J from IMSR.
View all literature mentionsMus musculus with name STOCK En1tm2(cre)Wrst/J from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsMus musculus with name B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J from IMSR.
View all literature mentions