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Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K+ channel (K2P) TWIK2 as the K+ efflux channel triggering NLRP3 inflammasome activation. Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6-/- macrophages into mouse airways after macrophage depletion also prevented inflammatory lung injury. The K+ efflux channel TWIK2 in macrophages has a fundamental role in activating the NLRP3 inflammasome and consequently mediates inflammation, pointing to TWIK2 as a potential target for anti-inflammatory therapies.
Pubmed ID: 29958799 RIS Download
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A commercial graphing software company that offers scientific software for statistical analyses, curve fitting and data analysis. It offers four programs: Prism, InStat, StatMate and QuickCalcs.
View all literature mentionsThis monoclonal targets Caspase-1
View all literature mentionsThis monoclonal targets NLRP3/NALP3
View all literature mentionsThis monoclonal targets TWIK-2 (H-6)
View all literature mentionsThis unknown targets KCNK2 Channel
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View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name B6N.129S2-Casp1tm1Flv/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-P2rx7tm1Gab/J from IMSR.
View all literature mentionsThis unknown targets KCNK2 Channel
View all literature mentionsThis polyclonal targets Mouse IL-1 beta / IL-1F2
View all literature mentionsThis monoclonal targets NLRP3/NALP3
View all literature mentionsThis monoclonal targets Caspase-1
View all literature mentionsThis monoclonal targets TWIK-2 (H-6)
View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
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