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Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor types, being lowest in sarcomas, whereas 90% of pancreatic ductal adenocarcinoma (PDAC) patients experience severe weight loss. How these tumors trigger muscle depletion is still unfolding. Serendipitously, we found that overexpression of Twist1 in mouse muscle progenitor cells, either constitutively during development or inducibly in adult animals, caused severe muscle atrophy with features reminiscent of cachexia. Using several genetic mouse models of PDAC, we detected a marked increase in Twist1 expression in muscle undergoing cachexia. In cancer patients, elevated levels of Twist1 are associated with greater degrees of muscle wasting. Finally, both genetic and pharmacological inactivation of Twist1 in muscle progenitor cells afforded substantial protection against cancer-mediated cachexia, which translated into meaningful survival benefits, implicating Twist1 as a possible target for attenuating muscle cachexia in cancer patients.
Pubmed ID: 29920276 RIS Download
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This polyclonal targets Dystrophin antibody
View all literature mentionsThis monoclonal targets Genetic locus: TWIST1 (human) mapping to 7p21.1; Twist1 (mouse) mapping to 12 A3. Raised against a recombinant protein corresponding to a region near the C-terminus of twist of human origin.
View all literature mentionsThis monoclonal targets Smad2 (D43B4) XP Rabbit mAb
View all literature mentionsThis polyclonal targets Mouse GDF-8
View all literature mentionsThis monoclonal targets PAX7 antibody [EPR3353]
View all literature mentionsThis polyclonal targets EIF3F
View all literature mentionsThis monoclonal targets Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb
View all literature mentionsThis monoclonal targets Raised against amino acids 1-552 representing full length Smad4 of human origin
View all literature mentionsThis polyclonal targets GDF8 / Myostatin
View all literature mentionsThis monoclonal targets Human Cytokeratin 19
View all literature mentionsThis monoclonal targets c-Myc
View all literature mentionsThis monoclonal targets MHC Class II
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets BrdU (Bu20a) Mouse mAb
View all literature mentionsMus musculus with name B6.129P2-Trp53tm1Brn/J from IMSR.
View all literature mentionsMus musculus with name B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(Prrx1-cre)1Cjt/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Pax7tm2.1(cre/ERT2)Fan/J from IMSR.
View all literature mentionsMus musculus with name STOCK Pax7tm1(cre)Mrc/J from IMSR.
View all literature mentionsMus musculus with name NOD.Cg-Prkdcscid/J from IMSR.
View all literature mentionsMus musculus with name FVB-Tg(CAG-cat.-Twist1)1Dbsp/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J from IMSR.
View all literature mentionsCell line LL/2 (LLC1) is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line CT26.WT is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line MIA PaCa-2 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line B16-F0 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsThis polyclonal targets Mouse GDF-8
View all literature mentionsThis polyclonal targets Dystrophin antibody
View all literature mentionsThis monoclonal targets Genetic locus: TWIST1 (human) mapping to 7p21.1; Twist1 (mouse) mapping to 12 A3. Raised against a recombinant protein corresponding to a region near the C-terminus of twist of human origin.
View all literature mentionsThis monoclonal targets Smad2 (D43B4) XP Rabbit mAb
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