The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate lymphoid cells (ILC2s) provided tissue-restricted T cell co-stimulation that was indispensable for Th2 and regulatory T (Treg) cell responses in the lung and adipose tissue. Interleukin (IL)-33 administration resulted in organ-specific surface expression of OX40L on ILC2s and the concomitant expansion of Th2 and Treg cells, which was abolished upon deletion of OX40L on ILC2s (Il7raCre/+Tnfsf4fl/fl mice). Moreover, Il7raCre/+Tnfsf4fl/fl mice failed to mount effective Th2 and Treg cell responses and corresponding adaptive type 2 pulmonary inflammation arising from Nippostrongylus brasiliensis infection or allergen exposure. Thus, the increased expression of OX40L in response to IL-33 acts as a licensing signal in the orchestration of tissue-specific adaptive type 2 immunity, without which this response fails to establish.
Pubmed ID: 29907525 RIS Download
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Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets CD252
View all literature mentionsThis monoclonal targets CD294
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD71
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets CD123
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets CD40
View all literature mentionsThis unknown targets Fluorescein/Oregon Green
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis monoclonal targets IL-33R (ST2)
View all literature mentionsThis monoclonal targets CD2
View all literature mentionsThis monoclonal targets IFN-gamma
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets Gata-3
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis polyclonal targets Murine Relm-alpha
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets IL-13
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Helios
View all literature mentionsThis monoclonal targets CD304
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentionsThis monoclonal targets CD252 (OX40 Ligand)
View all literature mentionsThis monoclonal targets CD134
View all literature mentionsThis monoclonal targets Mouse Neutrophil
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD152
View all literature mentionsThis monoclonal targets Gata-3
View all literature mentionsThis monoclonal targets ROR gamma (t)
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View all literature mentionsThis monoclonal targets FceR1 alpha
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View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
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View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsMus musculus with name B6.Cg-Rag2tm1.1Cgn/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Rag2tm1.1Cgn/J from IMSR.
View all literature mentionsThis monoclonal targets CD252
View all literature mentionsThis monoclonal targets CD294
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD71
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets CD123
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets CD40
View all literature mentionsThis unknown targets Fluorescein/Oregon Green
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis monoclonal targets IL-33R (ST2)
View all literature mentionsThis monoclonal targets CD2
View all literature mentionsThis monoclonal targets IFN-gamma
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets Gata-3
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis polyclonal targets Murine Relm-alpha
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets IL-13
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Helios
View all literature mentionsThis monoclonal targets CD304
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentionsThis monoclonal targets CD252 (OX40 Ligand)
View all literature mentionsThis monoclonal targets CD134
View all literature mentionsThis monoclonal targets Mouse Neutrophil
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD152
View all literature mentionsThis monoclonal targets Gata-3
View all literature mentionsThis monoclonal targets ROR gamma (t)
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets FceR1 alpha
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets Siglec-F
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