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A significant proportion of cancer patients do not respond to immune checkpoint blockade. To better understand the molecular mechanisms underlying these treatments, we explored the role of CD4+Foxp3- T cells expressing PD-1 (4PD1hi) and observed that 4PD1hi accumulate intratumorally as a function of tumor burden. Interestingly, CTLA-4 blockade promotes intratumoral and peripheral 4PD1hi increases in a dose-dependent manner, while combination with PD-1 blockade mitigates this effect and improves anti-tumor activity. We found that lack of effective 4PD1hi reduction after anti-PD-1 correlates with poor prognosis. Mechanistically, we provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells. Accordingly, anti-CTLA-4 activity is improved in TFH deficient mice.
Pubmed ID: 29894689 RIS Download
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsSoftware tool as a digital virtual microscope for viewing and moving scanned histological slides and for making annotations and measurements on them. Used in digital pathology. Helps to simplify the areas of the pathology workflow where imaging, slide digitization, storage, archivation, visualization and analysis are performed.
View all literature mentionsSoftware tool as a digital virtual microscope for viewing and moving scanned histological slides and for making annotations and measurements on them. Used in digital pathology. Helps to simplify the areas of the pathology workflow where imaging, slide digitization, storage, archivation, visualization and analysis are performed.
View all literature mentionsThis monoclonal targets H-2K[b]
View all literature mentionsThis monoclonal targets Human CD152
View all literature mentionsThis monoclonal targets CD152 (CTLA-4)
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD278 (ICOS)
View all literature mentionsThis monoclonal targets CD25 (IL-2 Receptor α)
View all literature mentionsThis monoclonal targets CD279 (PD-1)
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis monoclonal targets CD8
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD45RA
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis polyclonal targets Mouse CD4
View all literature mentionsThis monoclonal targets IL-21
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets CD278 (ICOS)
View all literature mentionsThis monoclonal targets CD274
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD25 (IL-2 Receptor α)
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD279 (PD-1)
View all literature mentionsThis monoclonal targets CD279 (PD-1)
View all literature mentionsThis monoclonal targets CD279 (PD-1)
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD45R / B220
View all literature mentionsThis monoclonal targets CD8 alpha
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis isotype control targets KLH
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets PD-L1 (B7-H1)
View all literature mentionsThis monoclonal targets PD-1 (CD279)
View all literature mentionsThis monoclonal targets CTLA-4 (CD152)
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View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsMus musculus with name B6.129S6-Sh2d1atm1Pls/J from IMSR.
View all literature mentionsMus musculus with name B6.129S-Batftm1.1Kmm/J from IMSR.
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Mus musculus with name B6.SJL-Ptprca Pepc
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name BALB/cJ from IMSR.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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