Searching across hundreds of databases
Heterochromatic repetitive satellite RNAs are extensively transcribed in a variety of human cancers, including BRCA1 mutant breast cancer. Aberrant expression of satellite RNAs in cultured cells induces the DNA damage response, activates cell cycle checkpoints, and causes defects in chromosome segregation. However, the mechanism by which satellite RNA expression leads to genomic instability is not well understood. Here we provide evidence that increased levels of satellite RNAs in mammary glands induce tumor formation in mice. Using mass spectrometry, we further show that genomic instability induced by satellite RNAs occurs through interactions with BRCA1-associated protein networks required for the stabilization of DNA replication forks. Additionally, de-stabilized replication forks likely promote the formation of RNA-DNA hybrids in cells expressing satellite RNAs. These studies lay the foundation for developing novel therapeutic strategies that block the effects of non-coding satellite RNAs in cancer cells.
Pubmed ID: 29861157 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal targets LMNB1
View all literature mentionsThis polyclonal targets Lamin A (C-terminal) antibody produced in rabbit
View all literature mentionsThis polyclonal targets Histone H3
View all literature mentionsThis polyclonal targets PCNA - Proliferation Marker
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis polyclonal targets Cytokeratin 5 antibody
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets H3K9me3
View all literature mentionsThis monoclonal targets DNA-RNA Hybrid
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis unknown targets Phospho-RPA32 (Ser4, Ser8)
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis monoclonal targets Histone H2A.X pSer139
View all literature mentionsThis unknown targets Phospho-RPA32 (Ser4, Ser8)
View all literature mentionsThis polyclonal targets Histone H3
View all literature mentionsThis monoclonal targets DNA-RNA Hybrid
View all literature mentionsThis polyclonal targets H3K9me3
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis monoclonal targets Histone H2A.X pSer139
View all literature mentionsThis polyclonal targets Lamin A (C-terminal) antibody produced in rabbit
View all literature mentionsThis polyclonal targets PCNA - Proliferation Marker
View all literature mentionsThis polyclonal targets Cytokeratin 5 antibody
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis polyclonal targets LMNB1
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
