Searching across hundreds of databases
Placodes are focal thickenings of the surface ectoderm which, together with neural crest, generate the peripheral nervous system of the vertebrate head. Here we examine how, in embryonic mice, apoptosis contributes to the remodelling of the primordial posterior placodal area (PPA) into physically separated otic and epibranchial placodes. Using pharmacological inhibition of apoptosis-associated caspases, we find evidence that apoptosis eliminates hitherto undiscovered rudiments of the lateral line sensory system which, in fish and aquatic amphibia, serves to detect movements, pressure changes or electric fields in the surrounding water. Our results refute the evolutionary theory, valid for more than a century that the whole lateral line was completely lost in amniotes. Instead, those parts of the PPA which, under experimental conditions, escape apoptosis have retained the developmental potential to produce lateral line placodes and the primordia of neuromasts that represent the major functional units of the mechanosensory lateral line system.
Pubmed ID: 29848488 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Commercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsAnalytics platform with various sub platforms, each with specific performance capabilities for tasks such as data analysis, data management, data visualization, and data mining procedures.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionslaboratory mouse with name C57BL/6N from MGI.
View all literature mentionsThis monoclonal targets Islet-1 & Islet-2 homeobox
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets IgG
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis unknown targets TBX3
View all literature mentionsThis monoclonal targets Sox-10 (A-2)
View all literature mentionsThis unknown targets Raised against peptide mapping to N-terminus of sox-10 of human origin
View all literature mentionsThis monoclonal targets Human SOX2
View all literature mentionsThis polyclonal targets SIX1 antibody produced in rabbit
View all literature mentionsThis polyclonal targets Phospho-Histone H3 (Ser10)
View all literature mentionsThis polyclonal targets PAX2
View all literature mentionsThis polyclonal targets NEUROD1
View all literature mentionsThis monoclonal targets Neurogenin-2
View all literature mentionsThis polyclonal targets Neurogenin 1
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets β-Tubulin III
View all literature mentionsThis monoclonal targets Math1 (Atoh1)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets IgG
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis unknown targets TBX3
View all literature mentionsThis monoclonal targets Sox-10 (A-2)
View all literature mentionsThis unknown targets Raised against peptide mapping to N-terminus of sox-10 of human origin
View all literature mentionsThis monoclonal targets Human SOX2
View all literature mentionsThis polyclonal targets SIX1 antibody produced in rabbit
View all literature mentionsThis polyclonal targets Phospho-Histone H3 (Ser10)
View all literature mentionsThis polyclonal targets PAX2
View all literature mentionsThis polyclonal targets NEUROD1
View all literature mentionsThis monoclonal targets Neurogenin-2
View all literature mentionsThis polyclonal targets Neurogenin 1
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets β-Tubulin III
View all literature mentionsThis monoclonal targets Math1 (Atoh1)
View all literature mentionsThis monoclonal targets Islet-1 & Islet-2 homeobox
View all literature mentionsThis monoclonal targets Islet-1 & Islet-2 homeobox
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
