Searching across hundreds of databases
A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here, we identify the vitamin D receptor (VDR) as a key modulator of inflammation and β cell survival. Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively. Mechanistically, ligand promotes VDR association with PBAF to effect genome-wide changes in chromatin accessibility and enhancer landscape, resulting in an anti-inflammatory response. Importantly, pharmacological inhibition of BRD9 promotes PBAF-VDR association to restore β cell function and ameliorate hyperglycemia in murine T2D models. These studies reveal an unrecognized VDR-dependent transcriptional program underpinning β cell survival and identifies the VDR:PBAF/BAF association as a potential therapeutic target for T2D.
Pubmed ID: 29754817 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
A commercial antibody supplier and provider of various services.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsThis monoclonal targets Phospho-PERK (Thr980)
View all literature mentionsThis monoclonal targets PERK (C33E10) Rabbit mAb
View all literature mentionsThis polyclonal targets Calnexin
View all literature mentionsThis recombinant monoclonal targets Ki67
View all literature mentionsThis monoclonal targets Human/Mouse Proinsulin MAb (Clone 253627)
View all literature mentionsThis polyclonal targets Insulin
View all literature mentionsThis monoclonal targets Glucagon
View all literature mentionsThis polyclonal targets H3K27ac
View all literature mentionsThis monoclonal targets IKKbeta (D30C6) Rabbit mAb
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets IkappaB-alpha
View all literature mentionsThis polyclonal targets Histone Deacetylase 3 (HDAC3)
View all literature mentionsThis unknown targets ARID1A/BAF250
View all literature mentionsThis polyclonal targets PHF10
View all literature mentionsThis unknown targets PBRM1
View all literature mentionsThis polyclonal targets Smarca4
View all literature mentionsThis monoclonal targets KAT2B
View all literature mentionsThis unknown targets GST
View all literature mentionsThis polyclonal targets Acetylated-Lysine
View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis monoclonal targets FLAG??
View all literature mentionsThis polyclonal targets VDR (C-20)
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
