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Different Neuronal Activity Patterns Induce Different Gene Expression Programs.

Neuron | May 2, 2018

A vast number of different neuronal activity patterns could each induce a different set of activity-regulated genes. Mapping this coupling between activity pattern and gene induction would allow inference of a neuron's activity-pattern history from its gene expression and improve our understanding of activity-pattern-dependent synaptic plasticity. In genome-scale experiments comparing brief and sustained activity patterns, we reveal that activity-duration history can be inferred from gene expression profiles. Brief activity selectively induces a small subset of the activity-regulated gene program that corresponds to the first of three temporal waves of genes induced by sustained activity. Induction of these first-wave genes is mechanistically distinct from that of the later waves because it requires MAPK/ERK signaling but does not require de novo translation. Thus, the same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations.

Pubmed ID: 29681534 RIS Download

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: DP2 DK105570
  • Agency: NIMH NIH HHS, Id: R01 MH116223
  • Agency: NIMH NIH HHS, Id: R01 MH101528
  • Agency: NIEHS NIH HHS, Id: Z01 ES100221
  • Agency: NICHD NIH HHS, Id: U54 HD090255
  • Agency: NIMH NIH HHS, Id: R00 MH096941
  • Agency: NIDDK NIH HHS, Id: R01 DK109930

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