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Empathy is crucial for our emotional experience and social interactions, and its abnormalities manifest in various psychiatric disorders. Observational fear is a useful behavioral paradigm for assessing affective empathy in rodents. However, specific genes that regulate observational fear remain unknown. Here we showed that 129S1/SvImJ mice carrying a unique missense variant in neurexin 3 (Nrxn3) exhibited a profound and selective enhancement in observational fear. Using the CRISPR/Cas9 system, the arginine-to-tryptophan (R498W) change in Nrxn3 was confirmed to be the causative variant. Selective deletion of Nrxn3 in somatostatin-expressing (SST+) interneurons in the anterior cingulate cortex (ACC) markedly increased observational fear and impaired inhibitory synaptic transmission from SST+ neurons. Concordantly, optogenetic manipulation revealed that SST+ neurons in the ACC bidirectionally controlled the degree of socially transmitted fear. Together, these results provide insights into the genetic basis of behavioral variability and the neurophysiological mechanism controlling empathy in mammalian brains.
Pubmed ID: 29681532 RIS Download
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This unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Cre Recombinase
View all literature mentionsMus musculus with name B6;129-Nrxn3tm3Sud/J from IMSR.
View all literature mentionsMus musculus with name STOCK Viptm1(cre)Zjh/J from IMSR.
View all literature mentionsMus musculus with name STOCK Ssttm3.1(flpo)Zjh/J from IMSR.
View all literature mentionsMus musculus with name B6;129P2-Pvalbtm1(cre)Arbr/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Nrxn3tm3Sud/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Nrxn3tm3Sud/J from IMSR.
View all literature mentionsMus musculus with name STOCK Ssttm3.1(flpo)Zjh/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Viptm1(cre)Zjh/J from IMSR.
View all literature mentionsMus musculus with name B6;129P2-Pvalbtm1(cre)Arbr/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Nrxn3tm3Sud/J from IMSR.
View all literature mentionsMus musculus with name STOCK Ssttm3.1(flpo)Zjh/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Viptm1(cre)Zjh/J from IMSR.
View all literature mentionsMus musculus with name B6;129P2-Pvalbtm1(cre)Arbr/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
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