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Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.

Redox biology | 2018

Reduction of oxidized methionines is emerging as a major protein repair pathway. The lack of methionine sulfoxide reductase A (MsrA) exacerbates cardiovascular disease phenotypes driven by increased oxidative stress. However, the role of MsrA on maintaining cellular homeostasis in the absence of excessive oxidative stress is less well understood.

Pubmed ID: 29649787 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL108932
  • Agency: NHLBI NIH HHS, United States
    Id: T32 HL007121
  • Agency: NIEHS NIH HHS, United States
    Id: P30 ES005605
  • Agency: NCI NIH HHS, United States
    Id: P30 CA086862
  • Agency: BLRD VA, United States
    Id: I01 BX000163
  • Agency: NCI NIH HHS, United States
    Id: R01 CA182804

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GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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Jackson Laboratory (tool)

RRID:SCR_004633

An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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