Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether plasticity during effector-to-memory CD8+ T cell differentiation affects memory lineage specification and functional versatility remains unclear. Using genetic fate mapping analysis of highly cytotoxic KLRG1+ effector CD8+ T cells, we demonstrated that KLRG1+ cells receiving intermediate amounts of activating and inflammatory signals downregulated KLRG1 during the contraction phase in a Bach2-dependent manner and differentiated into all memory T cell linages, including CX3CR1int peripheral memory cells and tissue-resident memory cells. "ExKLRG1" memory cells retained high cytotoxic and proliferative capacity distinct from other populations, which contributed to effective anti-influenza and anti-tumor immunity. Our work demonstrates that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long-term protective immunity.
Pubmed ID: 29625895 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsJava toolset for working with next generation sequencing data in the BAM format.
View all literature mentionsThis polyclonal targets Human BACH2
View all literature mentionsThis polyclonal targets ACTG1, ACTC1, ACTA1, ACTA2, ACTG2, ACTB
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets RFP Pre-adsorbed
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis monoclonal targets IFN-gamma
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets DYKDDDDK
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CD183
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD107a
View all literature mentionsThis monoclonal targets CD103
View all literature mentionsThis monoclonal targets CD103
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets Mouse CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD197
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets Bcl-2
View all literature mentionsMus musculus with name B6.Cg-Tg(Pgk1-flpo)10Sykr/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6-Tg(UBC-GFP)30Scha/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentions