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Identification of a resilient mouse facial motoneuron population following target disconnection by injury or disease.

Restorative neurology and neuroscience | 2018

When nerve transection is performed on adult rodents, a substantial population of neurons survives short-term disconnection from target, and the immune system supports this neuronal survival, however long-term survival remains unknown. Understanding the effects of permanent axotomy on cell body survival is important as target disconnection is the first pathological occurrence in fatal motoneuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).

Pubmed ID: 29614705 RIS Download

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FVB/NJ (organism)

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FVB.Cg-Smn1tm1Hung Tg(SMN2)2Hung/J (organism)

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B6SJL-Tg(SOD1*G93A)1Gur/J (organism)

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B6SJLF1/J (organism)

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B6.Cg-Rag2tm1.1Cgn/J (organism)

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C57BL/6J (organism)

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GraphPad (commercial organization)

RRID:SCR_000306

A commercial graphing software company that offers scientific software for statistical analyses, curve fitting and data analysis. It offers four programs: Prism, InStat, StatMate and QuickCalcs.

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