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Pancreatic ribonuclease (RNase) is a secreted enzyme critical for host defense. We discover an intrinsic RNase function, serving as a ligand for epidermal growth factor receptor (EGFR), a member of receptor tyrosine kinase (RTK), in pancreatic ductal adenocarcinoma (PDAC). The closely related bovine RNase A and human RNase 5 (angiogenin [ANG]) can trigger oncogenic transformation independently of their catalytic activities via direct association with EGFR. Notably, high plasma ANG level in PDAC patients is positively associated with response to EGFR inhibitor erlotinib treatment. These results identify a role of ANG as a serum biomarker that may be used to stratify patients for EGFR-targeted therapies, and offer insights into the ligand-receptor relationship between RNase and RTK families.
Pubmed ID: 29606349 RIS Download
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This monoclonal targets EGFR
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View all literature mentionsThis monoclonal targets Generated from carboxyl terminus of human c-neu gene product
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H + L)
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View all literature mentionsThis polyclonal targets Human EGF ylated Affinity Purified PAb
View all literature mentionsThis polyclonal targets Human EGF
View all literature mentionsThis polyclonal targets Human Angiogenin ylated Affinity Purified PAb
View all literature mentionsThis polyclonal targets Human Angiogenin Ab
View all literature mentionsThis polyclonal targets Human Angiogenin
View all literature mentionsThis monoclonal targets Angiogenin
View all literature mentionsThis polyclonal targets Cow Ribonuclease A (Biotin)
View all literature mentionsThis polyclonal targets Ribonuclease A antibody
View all literature mentionsThis polyclonal targets Ribonuclease A
View all literature mentionsThis monoclonal targets Phosphotyrosine
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View all literature mentionsThis polyclonal targets DYKDDDK
View all literature mentionsThis monoclonal targets c-myc; Mouse monoclonal antibody (clone 9E10) IgG1 & 954;
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View all literature mentionsThis monoclonal targets TCF8/ZEB1 (D80D3) Rabbit mAb
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View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
View all literature mentionsThis polyclonal targets MAP Kinase 1 / 2 (Erk1 / 2), CT
View all literature mentionsThis polyclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis unknown targets Her2 / ErbB2, phospho (Tyr1248)
View all literature mentionsThis monoclonal targets EGF Receptor, phospho (Tyr1173)
View all literature mentionsThis polyclonal targets Phospho-EGF Receptor (Tyr1148)
View all literature mentionsThis unknown targets Human EGF Receptor, phospho (Tyr1086)
View all literature mentionsThis monoclonal targets EGFR (phospho Y1068)
View all literature mentionsThis monoclonal targets Phospho-EGF Receptor (Tyr1068)
View all literature mentionsThis unknown targets EGF Receptor, phospho (Tyr1045)
View all literature mentionsThis unknown targets EGF Receptor, phospho (Tyr992)
View all literature mentionsThis monoclonal targets Human Epidermal Growth Factor Receptor
View all literature mentionsThis monoclonal targets EGF Receptor
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name J:NU from IMSR.
View all literature mentionsCell line MDBK is a Spontaneously immortalized cell line with a species of origin Bos taurus
View all literature mentionsCell line A-431 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NIH 3T3 is a Spontaneously immortalized cell line with a species of origin Mus musculus
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line BxPC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line CFPAC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line Capan-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HPAC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line AsPC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line PANC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
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