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Publication

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).

Molecular neurodegeneration | 2018

TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer's disease (AD) and other neurodegenerative diseases. While multiple studies support a role for TREM2 in microglial recruitment to amyloid plaques, the chemoattractant factor modulating TREM2-dependent microglial responses has not been defined.

Pubmed ID: 29587871 RIS Download

Research resources used in this publication

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Antibodies used in this publication

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: R37 AG027924
  • Agency: National Natural Science Foundation of China, International
    Id: 81771163
  • Agency: National Natural Science Foundation of China, International
    Id: U1405222
  • Agency: NIH HHS, United States
    Id: RF1AG056114
  • Agency: NIH HHS, United States
    Id: UM1 OD023221
  • Agency: Fundamental Research Funds for the Central Universities, International
    Id: 20720180055
  • Agency: NIH HHS, United States
    Id: RF1AG056130
  • Agency: National Natural Science Foundation of China, International
    Id: 81701079
  • Agency: Postdoctoral Science Foundation of China, International
    Id: 2017T100469
  • Agency: National Natural Science Foundation of China, International
    Id: U1505227
  • Agency: Postdoctoral Science Foundation of China, International
    Id: 2016M600503
  • Agency: National Natural Science Foundation of China, International
    Id: 81370459
  • Agency: National Natural Science Foundation of China, International
    Id: 31400914
  • Agency: NIA NIH HHS, United States
    Id: RF1 AG056130
  • Agency: Natural Science Foundation of Guangdong Province, International
    Id: 2016A030306005
  • Agency: NIH HHS, United States
    Id: R01AG035355

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AnaSpec (tool)

RRID:SCR_002114

Commercial supplier of antibodies, reagents, and dyes for research.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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