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Laminar arrangement of neural connections is a fundamental feature of neural circuit organization. Identifying mechanisms that coordinate neural connections within correct layers is thus vital for understanding how neural circuits are assembled. In the medulla of the Drosophila visual system neurons form connections within ten parallel layers. The M3 layer receives input from two neuron types that sequentially innervate M3 during development. Here we show that M3-specific innervation by both neurons is coordinated by Drosophila Fezf (dFezf), a conserved transcription factor that is selectively expressed by the earlier targeting input neuron. In this cell, dFezf instructs layer specificity and activates the expression of a secreted molecule (Netrin) that regulates the layer specificity of the other input neuron. We propose that employment of transcriptional modules that cell-intrinsically target neurons to specific layers, and cell-extrinsically recruit other neurons is a general mechanism for building layered networks of neural connections.
Pubmed ID: 29513217 RIS Download
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsA next-generation web-based application that aims to provide an integrated solution for both visualization and analysis of deep-sequencing data, along with simple access to public datasets.
View all literature mentionsA read summarization program, which counts mapped reads for the genomic features such as genes and exons.
View all literature mentionsSoftware package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}1, P{w[+mC]=tubP-GAL4}1, P{w[+mC]=UAS-GFP.T:Myc.T:nls2}1, y[1] w[*]; RpS17[4] P{w[+m*] ry[+t7.2]=white-un1}70C P{w[+mC]=tubP-GAL80}LL9 P{ry[+t7.2]=neoFRT}80B/TM6B, Tb[1] from BDSC.
View all literature mentionsThis polyclonal targets bab1
View all literature mentionsThis polyclonal targets bsh
View all literature mentionsThis monoclonal targets Seven-up
View all literature mentionsThis polyclonal targets erm
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG1
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Chicken IgG (H+L)
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis monoclonal targets cadherin, DN- (extracellular domain)
View all literature mentionsThis monoclonal targets elav Drosophila protein; embryonic lethal abnormal vision
View all literature mentionsThis monoclonal targets chaoptin
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis monoclonal targets MOUSE ANTI V5-TAG
View all literature mentionsThis monoclonal targets HA tag
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-RSR.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; PBac{y[+mDint2] w[+mC]=GMR39D12-lexA}VK00027/TM3, Sb[1] from BDSC.
View all literature mentionsData aggregate that compiles results from bioinformatics analyses across multiple samples into a single report. It is written in Python.
View all literature mentionsSoftware application written in Java and R that provides both a Graphical User Inteface (GUI) and a command-line interface to facilitate the quality control of alignment sequencing data. It examines sequencing alignment data in SAM / BAM files according to the features of the mapped reads and provides an overall view of the data that helps to the detect biases in the sequencing and/or mapping of the data and eases decision-making for further analysis.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsQuality control software that perform checks on raw sequence data coming from high throughput sequencing pipelines. This software also provides a modular set of analyses which can give a quick impression of the quality of the data prior to further analysis.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{PT-GFSTF.1}side-III[MI01139-GFSTF.1]/TM6C, Sb[1] Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{PT-GFSTF.0}beat-IIb[MI03102-GFSTF.0] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{PT-GFSTF.1}nrm[MI01630-GFSTF.1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{PT-GFSTF.1}dpr17[MI08707-GFSTF.1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] PBac{602.P.SVS-1}NetB[CPTI000168] from DGGR.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Rh6-EGFP.P}2/CyO; P{Rh6-EGFP.P}3/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02342}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR9B08-GAL4}attP2/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR24C08-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-Dcr-2.D}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=10XUAS(FRT.stop)GFP.Myr}su(Hw)attP5 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR16H03-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] P{y[+t7.7] w[+mC]=10XUAS-IVS-myr::GFP}su(Hw)attP8 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=lacW}Sema1a[k13702]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=R27G05-FLPG5.PEST}attP40/CyO, P{w[+mC]=GAL4-Kr.C}DC3, P{w[+mC]=UAS-GFP.S65T}DC7; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=tubP-GAL80}LL10 P{ry[+t7.2]=neoFRT}40A/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=10XUAS-IVS-myr::GFP}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-RSR.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-RSR.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-RSR.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; PBac{y[+mDint2] w[+mC]=GMR39D12-lexA}VK00027/TM3, Sb[1] from BDSC.
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