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Publication

Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice.

eLife | 2018

Down syndrome, the leading genetic cause of intellectual disability, results from an extra-copy of chromosome 21. Mice engineered to model this aneuploidy exhibit Down syndrome-like memory deficits in spatial and contextual tasks. While abnormal neuronal function has been identified in these models, most studies have relied on in vitro measures. Here, using in vivo recording in the Dp(16)1Yey model, we find alterations in the organization of spiking of hippocampal CA1 pyramidal neurons, including deficits in the generation of complex spikes. These changes lead to poorer spatial coding during exploration and less coordinated activity during sharp-wave ripples, events involved in memory consolidation. Further, the density of CA1 inhibitory neurons expressing neuropeptide Y, a population key for the generation of pyramidal cell bursts, were significantly increased in Dp(16)1Yey mice. Our data refine the 'over-suppression' theory of Down syndrome pathophysiology and suggest specific neuronal subtypes involved in hippocampal dysfunction in these model mice.

Pubmed ID: 29485402 RIS Download

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This is a list of tools and resources that we have found mentioned in this publication.

Jackson Laboratory (tool)

RRID:SCR_004633

An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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Neuropeptide Y (D7Y5A) XP® Rabbit mAb #11976 (antibody)

RRID:AB_2716286

This monoclonal targets Neuropeptide Y

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Anti-Parvalbumin Rabbit pAb (antibody)

RRID:AB_2173906

This polyclonal targets Pvalb

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Rabbit Anti-Somatostatin Antibody, Unconjugated (antibody)

RRID:AB_518614

This unknown targets Somatostatin-14

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Goat Anti-Rabbit IgG Antibody (H+L), Biotinylated (antibody)

RRID:AB_2313606

This polyclonal targets IgG

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Rabbit Anti-PCP-4 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_2236566

This polyclonal targets Pcp4

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Dp(16Lipi-Zbtb21)1Yey/Dp(16Lipi-Zbtb21)1Yey (organism)

RRID:MGI:5690055

Allele Detail: Targeted This is a legacy resource.

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ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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MATLAB (software resource)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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