Searching across hundreds of databases
Cell growth and cell differentiation are two distinct yet coupled developmental processes, but how they are coordinated is not well understood. During Drosophila oogenesis, we found that the growth-promoting InR/Akt/TOR pathway was involved in suppressing the fate determination of the migratory border cells. The InR/Akt/TOR pathway signals through TOR and Raptor, components of TORC1, to downregulate the JAK/STAT pathway, which is necessary and sufficient for border cell fate determination. TORC1 promotes the protein stability of SOCS36E, the conserved negative regulator of JAK/STAT signaling, through physical interaction, suggesting that TORC1 acts as a key regulator coordinating both cell growth and cell differentiation.
Pubmed ID: 29456138 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H + L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Multi Ubiquitin
View all literature mentionsThis monoclonal targets beta Actin
View all literature mentionsThis polyclonal targets Phospho-Drosophila Akt (Ser505)
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis unknown targets Protein A/G PLUS-Agarose
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets c-Myc
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis monoclonal targets tubulin (alpha-)
View all literature mentionsThis monoclonal targets Fasciclin III (Drosophila)
View all literature mentionsThis monoclonal targets singed (fascin)
View all literature mentionsThis monoclonal targets beta-galactosidase
View all literature mentionsDrosophila melanogaster with name P{w[+mW.hs]=GawB}c306, w[1118] from DGGR.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Thor.LL}s/TM6C, cu[1] Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF01086}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF01088}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-GFP.nls}14 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=arm-lacZ.V}36BC P{ry[+t7.2]=neoFRT}40A/CyO, P{ry[+t7.2]=sevRas1.V12}FK1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{ry[+t7.2]=neoFRT}82B P{w[+mC]=arm-lacZ.V}83B/TM6C, Sb[1] Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=10XStat92E-GFP}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Tor[DeltaP] P{ry[+t7.2]=neoFRT}40A/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{y[+mDint2] w[+mC]=EPgy2}Akt[EY10012]/TM3, Sb[1] Ser[1] from BDSC.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
