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Oligodendrocyte death, neuroinflammation, and the effects of minocycline in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION).

Molecular vision | 2017

Optic nerve (ON) damage following nonarteritic anterior ischemic optic neuropathy (NAION) and its models is associated with neurodegenerative inflammation. Minocycline is a tetracycline derivative antibiotic believed to exert a neuroprotective effect by selective alteration and activation of the neuroinflammatory response. We evaluated minocycline's post-induction ability to modify early and late post-ischemic inflammatory responses and its retinal ganglion cell (RGC)-neuroprotective ability.

Pubmed ID: 29386871 RIS Download

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Molecular Probes (tool)

RRID:SCR_013318

An Antibody supplier and subset of ThermoFisher Scientific which provides fluorescence reagents for various experiments and methods.

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Dako (tool)

RRID:SCR_013530

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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CD68 antibody [ED1] (antibody)

RRID:AB_1141557

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caspase-3 (L-18) (antibody)

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Anti-NG2 Chondroitin Sulfate Proteoglycan (antibody)

RRID:AB_91789

This polyclonal targets NG2 Chondroitin Sulfate Proteoglycan

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Anti Iba1, Rabbit antibody (antibody)

RRID:AB_839504

This polyclonal targets Iba1

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UGT Antibody (antibody)

RRID:AB_11016938

This unknown targets UGT

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