Searching across hundreds of databases
Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the defining properties of such responses. Here, we show that a skin commensal can induce T cell responses in a manner that is restricted to non-classical MHC class I molecules. These responses are uncoupled from inflammation and highly distinct from pathogen-induced cells. Commensal-specific T cells express a defined gene signature that is characterized by expression of effector genes together with immunoregulatory and tissue-repair signatures. As such, non-classical MHCI-restricted commensal-specific immune responses not only promoted protection to pathogens, but also accelerated skin wound closure. Thus, the microbiota can induce a highly physiological and pleiotropic form of adaptive immunity that couples antimicrobial function with tissue repair. Our work also reveals that non-classical MHC class I molecules, an evolutionarily ancient arm of the immune system, can promote homeostatic immunity to the microbiota.
Pubmed ID: 29358051 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This unknown targets Rat Gamma Globulin
View all literature mentionsThis unknown targets Goat Serum
View all literature mentionsThis unknown targets Chicken IgY(IgG) (H+L)
View all literature mentionsThis unknown targets Keratin 14
View all literature mentionsThis unknown targets TCR Vb Screening Panel
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets Human IFN-g
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets CD8
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets ROR gamma (t)
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets TCR V gamma 3
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Mouse Ly-6G
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD122
View all literature mentionsThis monoclonal targets CD103 (Integrin alpha E)
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD49f (Integrin alpha 6)
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8b
View all literature mentionsThis monoclonal targets CD8b
View all literature mentionsThis monoclonal targets CD8b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentions
Mus musculus with name B6.129P2-H2-K1b-tm1Bpe H2-D1
Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsSoftware Java pipeline for trimming tasks for Illumina paired end and single ended data. Flexible Trimmer for Illumina Sequence Data. Pair aware preprocessing tool optimized for Illumina next generation sequencing data. Includes several processing steps for read trimming and filtering. Operating systems Unix/Linux, Mac OS, Windows.
View all literature mentionsSoftware package for quantifying gene and isoform abundances from single end or paired end RNA Seq data. Accurate transcript quantification from RNA Seq data with or without reference genome. Used for accurate quantification of gene and isoform expression from RNA-Seq data.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsQuality control software that perform checks on raw sequence data coming from high throughput sequencing pipelines. This software also provides a modular set of analyses which can give a quick impression of the quality of the data prior to further analysis.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 30,2023. Software for differential gene expression analysis based on the negative binomial distribution. It estimates variance-mean dependence in count data from high-throughput sequencing assays and tests for differential expression.
View all literature mentionsgene symbol note: interleukin 17A; mutant stock: targeted mutation 1.1, Brigitta Stockinger, targeted mutation 1.1, Brigitta Stockinger This is a legacy resource.
View all literature mentionsMus musculus with name B6.129P2-Tcrdtm1Mom/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Tap1tm1Arp/J from IMSR.
View all literature mentionsMus musculus with name B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J from IMSR.
View all literature mentionsMus musculus with name SJL/JCrNTac from IMSR.
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsMus musculus with name BALB/cJ from IMSR.
View all literature mentionsMus musculus with name C57BL/6NTac from IMSR.
View all literature mentions
Mus musculus with name B6.129P2-H2-K1b-tm1Bpe H2-D1
Imaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
