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Publication

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.

Cancer cell | 2018

Intratumoral CD103+ dendritic cells (DCs) are necessary for anti-tumor immunity. Here we evaluated the expression of immune regulators by CD103+ DCs in a murine model of breast cancer and identified expression of TIM-3 as a target for therapy. Anti-TIM-3 antibody improved response to paclitaxel chemotherapy in models of triple-negative and luminal B disease, with no evidence of toxicity. Combined efficacy was CD8+ T cell dependent and associated with increased granzyme B expression; however, TIM-3 expression was predominantly localized to myeloid cells in both human and murine tumors. Gene expression analysis identified upregulation of Cxcl9 within intratumoral DCs during combination therapy, and therapeutic efficacy was ablated by CXCR3 blockade, Batf3 deficiency, or Irf8 deficiency.

Pubmed ID: 29316433 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R00 CA185325
  • Agency: NCI NIH HHS, United States
    Id: R01 CA155331
  • Agency: NCI NIH HHS, United States
    Id: P30 CA076292
  • Agency: NCI NIH HHS, United States
    Id: U54 CA163123
  • Agency: NCI NIH HHS, United States
    Id: K99 CA185325

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ImmPRESS® HRP Horse Anti-Rabbit IgG Polymer Detection Kit, Peroxidase (antibody)

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Rat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (antibody)

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