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Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.

Journal of neuroinflammation | 2018

Exposure of the developing brain to immune mediators, including antibodies, is postulated to increase risk for neurodevelopmental disorders and neurodegenerative disease. It has been suggested that immunoglobulin G-immune complexes (IgG-IC) activate Fc gamma receptors (FcγR) expressed on neurons to modify signaling events in these cells. However, testing this hypothesis is hindered by a paucity of data regarding neuronal FcγR expression and function.

Pubmed ID: 29306331 RIS Download

Research resources used in this publication

Antibodies used in this publication

Associated grants

  • Agency: NIEHS NIH HHS, United States
    Id: P01 ES011269
  • Agency: NICHD NIH HHS, United States
    Id: U54 HD079125
  • Agency: NIEHS NIH HHS, United States
    Id: P42 ES004699
  • Agency: NIEHS NIH HHS, United States
    Id: P30 ES023513

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RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions

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RRID:AB_220152

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MOUSE IgG (H&L) Antibody IRDye800 Conjugated Pre-adsorbed (antibody)

RRID:AB_220125

This polyclonal targets MOUSE IgG (H&L) IRDye800 Pre-adsorbed

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb (antibody)

RRID:AB_331768

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb

View all literature mentions

mouse-IgG-control-human (antibody)

RRID:AB_737182

This unknown targets mouse-IgG-control

View all literature mentions

FlowJo (software resource)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

View all literature mentions

Image Studio Lite (software resource)

RRID:SCR_014211

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 28,2023. Software application which can analyze basic Western blot data and export them for use in spreadsheet programs. Users can create standardized or custom lab reports and can share them with colleagues. Image Studio Lite has been discontinued and replaced with Empiria Studio Software.

View all literature mentions

CD16 antibody [EPR4333] (antibody)

RRID:AB_10863447

This monoclonal targets CD16 antibody [EPR4333]

View all literature mentions

Anti-GFAP (antibody)

RRID:AB_10641162

This polyclonal targets GFAP

View all literature mentions

Anti-MAP 2 (antibody)

RRID:AB_2138181

This polyclonal targets MAP 2

View all literature mentions

CD32 (antibody)

RRID:AB_393568

This monoclonal targets CD32

View all literature mentions

CD64 (H-250) (antibody)

RRID:AB_2103451

This polyclonal targets FCGR1A, FCGR1B, FCGR1C

View all literature mentions

Anti-GFAP (antibody)

RRID:AB_10641162

This polyclonal targets GFAP

View all literature mentions

Anti-MAP 2 (antibody)

RRID:AB_2138181

This polyclonal targets MAP 2

View all literature mentions

CD32 (antibody)

RRID:AB_393568

This monoclonal targets CD32

View all literature mentions

CD64 (H-250) (antibody)

RRID:AB_2103451

This polyclonal targets FCGR1A, FCGR1B, FCGR1C

View all literature mentions