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Publication

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.

Molecular cell | 2017

Enhancer elements are genomic regulatory sequences that direct the selective expression of genes so that genetically identical cells can differentiate and acquire the highly specialized forms and functions required to build a functioning animal. To differentiate, cells must select from among the ∼106 enhancers encoded in the genome the thousands of enhancers that drive the gene programs that impart their distinct features. We used a genetic approach to identify transcription factors (TFs) required for enhancer selection in fibroblasts. This revealed that the broadly expressed, growth-factor-inducible TFs FOS/JUN (AP-1) play a central role in enhancer selection. FOS/JUN selects enhancers together with cell-type-specific TFs by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. These experiments demonstrate how environmental signals acting via FOS/JUN and BAF coordinate with cell-type-specific TFs to select enhancer repertoires that enable differentiation during development.

Pubmed ID: 29272704 RIS Download

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Associated grants

Agency: NCI NIH HHS, United States
Id: K99 CA197640
Agency: NINDS NIH HHS, United States
Id: R01 NS048276
Agency: NINDS NIH HHS, United States
Id: R37 NS028829
Agency: NICHD NIH HHS, United States
Id: U54 HD090255
Agency: Howard Hughes Medical Institute, United States

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