Searching across hundreds of databases
Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in both mouse and human GCs. CCR6+ GC B cells were highly enriched within the GC light zone (LZ), were the most quiescent of all GC B cells, exhibited a cell-surface phenotype and gene expression signature indicative of an MBC transition, and possessed the augmented response characteristics of MBCs. MBC precursors within the GC LZ predominantly possessed a low affinity for antigen but also included cells from within the high-affinity pool. These data indicate a fundamental dichotomy between the processes that drive MBC and PC differentiation during GC responses.
Pubmed ID: 29262350 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsSoftware package for efficient manipulation of biological strings. Memory efficient string containers, string matching algorithms, and other utilities, for fast manipulation of large biological sequences or sets of sequences.
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis unknown targets CD267
View all literature mentionsThis monoclonal targets CD31 (PECAM-1)
View all literature mentionsThis monoclonal targets CD83
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD138
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD10
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets Bcl-2
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD45R / B220
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD138
View all literature mentionsThis monoclonal targets CD10
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD31 (PECAM-1)
View all literature mentionsThis monoclonal targets CD83
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis unknown targets CD267
View all literature mentionsThis monoclonal targets Bcl-2
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsThis unknown targets
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
