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Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have identified a CD49a+Eomes+ subset of NK cells that secreted growth-promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction. The transcription factor Nfil3, but not T-bet, affected the function and the number of this decidual NK cell subset. Adoptive transfer of induced CD49a+Eomes+ NK cells reversed impaired fetal growth and rebuilt an appropriate local microenvironment. These findings reveal properties of NK cells in promoting fetal growth. In addition, this research proposes approaches for therapeutic administration of NK cells in order to reverse restricted nourishments within the uterine microenvironment during early pregnancy.
Pubmed ID: 29262349 RIS Download
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This monoclonal targets T-bet
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View all literature mentionsThis unknown targets Mouse CD335 (NKp46) Alexa Fluor® 647 (To Be Discontinued. Refer to NEW Format: eFluor® 660 cat. 50-3351) 25 ug
View all literature mentionsThis monoclonal targets CD49a
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View all literature mentionsThis monoclonal targets EOMES
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View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets CD45
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View all literature mentionsThis monoclonal targets CD85d (ILT4)
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets Human NCAM1
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View all literature mentionsThis monoclonal targets HLA-G
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View all literature mentionsThis monoclonal targets CD85j
View all literature mentionsThis monoclonal targets CD49a
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets CD158d
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View all literature mentionsThis monoclonal targets CD8
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD8
View all literature mentionsThis monoclonal targets ITGAM
View all literature mentionsThis monoclonal targets CD16 (FcγRIII)
View all literature mentionsThis monoclonal targets CD9
View all literature mentionsThis monoclonal targets CD11b (Mac-1)
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD49a
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD49a
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets CD85j
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets Human NCAM1
View all literature mentionsThis monoclonal targets CD85j
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets CD158d
View all literature mentionsThis monoclonal targets HLA-G
View all literature mentionsThis monoclonal targets CD85d (ILT4)
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets CD85d
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis polyclonal targets SPP1 / Osteopontin
View all literature mentionsThis unknown targets Mouse CD335 (NKp46) Alexa Fluor® 647 (To Be Discontinued. Refer to NEW Format: eFluor® 660 cat. 50-3351) 25 ug
View all literature mentionsThis monoclonal targets CD335
View all literature mentionsThis monoclonal targets CD49b (Integrin α2 chain)
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets HLA G antibody [G233]
View all literature mentionsThis monoclonal targets HLA-G
View all literature mentionsThis monoclonal targets CD158d
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets Human HLA-ABC
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