Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metastasis. Here, we report the development of a highly effective fully human monoclonal antibody against Jagged1 (clone 15D11). In addition to its inhibitory effect on bone metastasis of Jagged1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells. We further confirm the bone metastasis-promoting function of osteoblast-derived Jagged1 using osteoblast-specific Jagged1 transgenic mouse model. These findings establish 15D11 as a potential therapeutic agent for the prevention or treatment of bone metastasis.
Pubmed ID: 29232552 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This monoclonal secondary targets IgG
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal targets Mouse IL-6
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
View all literature mentionsThis unknown targets anti CD339 / JAG1 (110-125)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets beta Actin
View all literature mentionsThis monoclonal targets Human Alkaline Phosphatase/ALPL MAb (Clone 388828)
View all literature mentionsMus musculus with name NU/J from IMSR.
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsMus musculus with name BALB/cJ from IMSR.
View all literature mentionsCell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line CHO-K1 is a Spontaneously immortalized cell line with a species of origin Cricetulus griseus (Chinese hamster)
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line 4T1.2 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentions