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Publication

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.

Immunity | 2017

CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplantation. IRF4 deletion in mice resulted in progressive establishment of CD4+ T cell dysfunction and long-term allograft survival. Mechanistically, IRF4 repressed PD-1, Helios, and other molecules associated with T cell dysfunction. In the absence of IRF4, chromatin accessibility and binding of Helios at PD-1 cis-regulatory elements were increased, resulting in enhanced PD-1 expression and CD4+ T cell dysfunction. The dysfunctional state of Irf4-deficient T cells was initially reversible by PD-1 ligand blockade, but it progressively developed into an irreversible state. Hence, IRF4 controls a core regulatory circuit of CD4+ T cell dysfunction, and targeting IRF4 represents a potential therapeutic strategy for achieving transplant acceptance.

Pubmed ID: 29221730 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI106200

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

LEAF™ Purified anti-mouse CD3? (antibody)

RRID:AB_312679

This monoclonal targets CD3epsilon

View all literature mentions

Histone H3K9me3 Antibody (antibody)

RRID:AB_2687870

This monoclonal targets H3K9me3

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PE/Cyanine7 anti-mouse CD71 (antibody)

RRID:AB_2203382

This monoclonal targets CD71

View all literature mentions

APC anti-mouse CD279 (PD-1) (antibody)

RRID:AB_2159183

This monoclonal targets CD279

View all literature mentions

Rabbit Anti-Goat Rabbit anti-goat IgG-HRP Polyclonal, Hrp Conjugated (antibody)

RRID:AB_656964

This polyclonal targets Goat IgG

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PE anti-mouse CD3epsilon (antibody)

RRID:AB_312673

This monoclonal targets CD3epsilon

View all literature mentions

CD69 Monoclonal Antibody (H1.2F3), PE, eBioscience (antibody)

RRID:AB_465732

This monoclonal targets CD69

View all literature mentions

CD278 (ICOS) Monoclonal Antibody (C398.4A), PE, eBioscience (antibody)

RRID:AB_466277

This monoclonal targets CD278 (ICOS)

View all literature mentions

Alexa Fluor(R) 647 anti-human/mouse Granzyme B (antibody)

RRID:AB_2566333

This monoclonal targets Granzyme B

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Anti-mouse IgG, HRP-linked Antibody (antibody)

RRID:AB_330924

This polyclonal targets IgG

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rat IgG2b I sotype control (antibody)

RRID:AB_1107780

This isotype control targets KLH

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CD25 Monoclonal Antibody (PC61.5), APC, eBioscience (antibody)

RRID:AB_469366

This monoclonal targets CD25

View all literature mentions

Perforin Monoclonal Antibody (eBioOMAK-D), PE, eBioscience (antibody)

RRID:AB_466243

This monoclonal targets Perforin

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CD366 (TIM3) Monoclonal Antibody (8B.2C12), PE, eBioscience (antibody)

RRID:AB_465976

This monoclonal targets CD366 (TIM3)

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Streptavidin-Allophycocyanin (antibody)

RRID:AB_10050396

This unknown targets Streptavidin-Allophycocyanin

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Ki-67 Monoclonal Antibody (SolA15), PE-Cyanine7, eBioscience (antibody)

RRID:AB_11220070

This monoclonal targets Ki-67

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PE anti-mouse/human KLRG1 (MAFA) (antibody)

RRID:AB_10574313

This monoclonal targets KLRG1

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InVivoPlus anti-mouse CD25 (IL-2Rα) (antibody)

RRID:AB_1107619

This monoclonal targets CD25 (IL-2Rα)

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CXCR5 (antibody)

RRID:AB_394301

This monoclonal targets CXCR5

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Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

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PE anti-mouse IL-4 (antibody)

RRID:AB_315318

This monoclonal targets IL-4

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PE anti-mouse CD244.2 (2B4 B6 Alloantigen) (antibody)

RRID:AB_1626231

This monoclonal targets CD244.2

View all literature mentions

FOXP3 Monoclonal Antibody (FJK-16s), PE, eBioscience (antibody)

RRID:AB_465936

This monoclonal targets FOXP3

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InVivoPlus anti-mouse CD8α (antibody)

RRID:AB_1107671

This monoclonal targets CD8α

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Bcl-6 (antibody)

RRID:AB_10717126

This monoclonal targets Bcl-6

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APC/Cyanine7 anti-mouse CD45.1 (antibody)

RRID:AB_313505

This monoclonal targets CD45.1

View all literature mentions

β-Actin (8H10D10) Mouse mAb (HRP Conjugate) (antibody)

RRID:AB_2566811

This monoclonal targets

View all literature mentions

CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), PE, eBioscience (antibody)

RRID:AB_466089

This monoclonal targets CD274 (PD-L1, B7-H1)

View all literature mentions

APC/Cyanine7 anti-mouse CD45 (antibody)

RRID:AB_312981

This monoclonal targets CD45

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anti-mouse CD4 (antibody)

RRID:AB_1107636

This monoclonal targets CD4

View all literature mentions

GM-CSF Monoclonal Antibody (MP1-22E9), PE, eBioscience (antibody)

RRID:AB_466205

This monoclonal targets GM-CSF

View all literature mentions

BATF (D7C5) Rabbit mAb (antibody)

RRID:AB_11141425

This monoclonal targets BATF

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TNF alpha Monoclonal Antibody (MP6-XT22), PE, eBioscience (antibody)

RRID:AB_466199

This monoclonal targets TNF alpha

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APC anti-mouse CD223 (LAG-3) (antibody)

RRID:AB_10639935

This monoclonal targets CD223

View all literature mentions

CD3e Monoclonal Antibody (145-2C11), PerCP-Cyanine5.5, eBioscience (antibody)

RRID:AB_1107000

This monoclonal targets CD3e

View all literature mentions

InVivoPlus anti-mouse CTLA-4 (CD152) (antibody)

RRID:AB_10949609

This monoclonal targets CTLA-4 (CD152)

View all literature mentions

IL-13 Monoclonal Antibody (eBio13A), PerCP-eFluor™ 710, eBioscience (antibody)

RRID:AB_11218496

This monoclonal targets IL-13

View all literature mentions

PE/Cyanine7 anti-mouse TCR beta chain (antibody)

RRID:AB_893625

This monoclonal targets TCR beta chain

View all literature mentions

PE anti-mouse IL-17A (antibody)

RRID:AB_315464

This monoclonal targets IL-17A

View all literature mentions

InVivoPlus anti-mouse PD-L1 (B7-H1) (antibody)

RRID:AB_10949073

This monoclonal targets PD-L1 (B7-H1)

View all literature mentions

Alexa Fluor(R) 647 anti-mouse IL-17F (antibody)

RRID:AB_10578083

This monoclonal targets IL-17F

View all literature mentions

Alexa Fluor(R) 700 anti-mouse IL-2 (antibody)

RRID:AB_528931

This monoclonal targets IL-2

View all literature mentions

Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647 (antibody)

RRID:AB_2535864

This polyclonal secondary targets IgG (H+L)

View all literature mentions

PE anti-mouse IFN-gamma (antibody)

RRID:AB_315402

This monoclonal targets IFN-gamma

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CD152 (CTLA-4) Monoclonal Antibody (UC10-4B9), APC, eBioscience (antibody)

RRID:AB_2016700

This monoclonal targets CD152 (CTLA-4)

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Donkey Anti-Goat IgG (H+L) Antibody, Alexa Fluor 488 Conjugated (antibody)

RRID:AB_2534102

This unknown targets IgG (H+L)

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normal rabbit IgG (antibody)

RRID:AB_737197

This unknown targets normal rabbit IgG

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Glucose Transporter GLUT1 antibody [SPM498] (antibody)

RRID:AB_2190927

This monoclonal targets SLC2A1

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Alexa Fluor(R) 647 anti-mouse IL-10 (antibody)

RRID:AB_493511

This monoclonal targets IL-10

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IRF4-human (antibody)

RRID:AB_2127145

This polyclonal targets IRF4

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Alexa Fluor(R) 647 anti-mouse CD272 (BTLA) (antibody)

RRID:AB_10613297

This monoclonal targets CD272

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Helios (M-20) (antibody)

RRID:AB_2124965

This polyclonal targets Helios (M-20)

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Peanut agglutinin (PNA) (antibody)

RRID:AB_2315097

This unknown targets

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PE anti-mouse CD98 (4F2) (antibody)

RRID:AB_1186107

This monoclonal targets CD98

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Histone H4ac (pan-acetyl) antibody (antibody)

RRID:AB_2687872

This polyclonal targets Histone H4ac (pan-acetyl)

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PE anti-mouse FR4 (Folate Receptor 4) (antibody)

RRID:AB_1236541

This monoclonal targets FR4

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Pacific Blue(TM) anti-MU/HU GL7 Antigen (T/B Cell Act. Marker) (antibody)

RRID:AB_2563292

This monoclonal targets GL7

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TCR V beta 6 Monoclonal Antibody (RR4-7), PerCP-eFluor™ 710, eBioscience (antibody)

RRID:AB_11150054

This monoclonal targets TCR V beta 6

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APC anti-mouse CD73 (antibody)

RRID:AB_11219400

This monoclonal targets CD73

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Histone H3ac (pan-acetyl) antibody (antibody)

RRID:AB_2687871

This polyclonal targets Histone H3ac (pan-acetyl)

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PE anti-mouse CD160 (antibody)

RRID:AB_10960743

This monoclonal targets CD160

View all literature mentions

Mouse Anti-Histone H3, acetyl (Lys4), trimethyl ChIPAb+ Monoclonal Antibody, Unconjugated (antibody)

RRID:AB_1977250

This monoclonal targets Histone H3, acetyl (Lys4), trimethyl

View all literature mentions

PE/Cyanine5 anti-mouse CD19 (antibody)

RRID:AB_313645

This monoclonal targets CD19

View all literature mentions

FITC anti-mouse TCR Valpha2 (antibody)

RRID:AB_1134188

This monoclonal targets TCR Valpha2

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Alexa Fluor(R) 700 anti-mouse CD45.2 (antibody)

RRID:AB_493731

This monoclonal targets CD45.2

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PE/Cyanine7 anti-mouse CD138 (Syndecan-1) (antibody)

RRID:AB_2562198

This monoclonal targets CD138

View all literature mentions

HELIOS Monoclonal Antibody (22F6), PE, eBioscience (antibody)

RRID:AB_2572758

This monoclonal targets HELIOS

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PE anti-mouse CD226 (DNAM-1) (antibody)

RRID:AB_1186120

This monoclonal targets CD226

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CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience (antibody)

RRID:AB_465863

This monoclonal targets CD137 (4-1BB)

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PE anti-mouse CD357 (GITR) (antibody)

RRID:AB_1089132

This monoclonal targets CD357

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CD44 Monoclonal Antibody (IM7), Alexa Fluor™ 700, eBioscience (antibody)

RRID:AB_494011

This monoclonal targets CD44

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FITC anti-mouse CD62L (antibody)

RRID:AB_313093

This monoclonal targets CD62L

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Pacific Blue(TM) anti-mouse CD8a (antibody)

RRID:AB_493425

This monoclonal targets CD8a

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PE/Cyanine7 anti-mouse CD4 (antibody)

RRID:AB_312707

This monoclonal targets CD4

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C57BL/6J (organism)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

View all literature mentions

B6.Cg-Foxp3tm1.1Mal/J (organism)

RRID:IMSR_JAX:018628

Mus musculus with name B6.Cg-Foxp3tm1.1Mal/J from IMSR.

View all literature mentions

GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions

PANTHER (data analysis service)

RRID:SCR_004869

System that classifies genes by their functions, using published scientific experimental evidence and evolutionary relationships to predict function even in absence of direct experimental evidence. Orthologs view is curated orthology relationships between genes for human, mouse, rat, fish, worm, and fly.

View all literature mentions

FlowJo (software resource)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

View all literature mentions

Irf4tm1Mak/Irf4tm1Mak (organism)

RRID:MGI:3584108

Allele Detail: Targeted This is a legacy resource.

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B6.Cg-Tg(Tcra.Tcrb)3Ayr/J (organism)

RRID:IMSR_JAX:005655

Mus musculus with name B6.Cg-Tg(Tcra.Tcrb)3Ayr/J from IMSR.

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B6.SJL-Ptprca Pepc/BoyJ (organism)

RRID:IMSR_JAX:002014

Mus musculus with name B6.SJL-Ptprca Pepc/BoyJ from IMSR.

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B6.129S7-Rag1tm1Mom/J (organism)

RRID:IMSR_JAX:002216

Mus musculus with name B6.129S7-Rag1tm1Mom/J from IMSR.

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B6.129S1-Irf4tm1Rdf/J (organism)

RRID:IMSR_JAX:009380

Mus musculus with name B6.129S1-Irf4tm1Rdf/J from IMSR.

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B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ (organism)

RRID:IMSR_JAX:022071

Mus musculus with name B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ from IMSR.

View all literature mentions

BALB/cJ (organism)

RRID:IMSR_JAX:000651

Mus musculus with name BALB/cJ from IMSR.

View all literature mentions

IL-13 Monoclonal Antibody (eBio13A), PerCP-eFluor™ 710, eBioscience (antibody)

RRID:AB_11218496

This monoclonal targets IL-13

View all literature mentions

GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions

PANTHER (data analysis service)

RRID:SCR_004869

System that classifies genes by their functions, using published scientific experimental evidence and evolutionary relationships to predict function even in absence of direct experimental evidence. Orthologs view is curated orthology relationships between genes for human, mouse, rat, fish, worm, and fly.

View all literature mentions

FlowJo (software resource)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

View all literature mentions

Irf4tm1Mak/Irf4tm1Mak (organism)

RRID:MGI:3584108

Allele Detail: Targeted This is a legacy resource.

View all literature mentions

LEAF™ Purified anti-mouse CD3? (antibody)

RRID:AB_312679

This monoclonal targets CD3epsilon

View all literature mentions

PE anti-mouse CD3epsilon (antibody)

RRID:AB_312673

This monoclonal targets CD3epsilon

View all literature mentions

rat IgG2b I sotype control (antibody)

RRID:AB_1107780

This isotype control targets KLH

View all literature mentions

InVivoPlus anti-mouse CD25 (IL-2Rα) (antibody)

RRID:AB_1107619

This monoclonal targets CD25 (IL-2Rα)

View all literature mentions

InVivoPlus anti-mouse CD8α (antibody)

RRID:AB_1107671

This monoclonal targets CD8α

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anti-mouse CD4 (antibody)

RRID:AB_1107636

This monoclonal targets CD4

View all literature mentions

InVivoPlus anti-mouse CTLA-4 (CD152) (antibody)

RRID:AB_10949609

This monoclonal targets CTLA-4 (CD152)

View all literature mentions

InVivoPlus anti-mouse PD-L1 (B7-H1) (antibody)

RRID:AB_10949073

This monoclonal targets PD-L1 (B7-H1)

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normal rabbit IgG (antibody)

RRID:AB_737197

This unknown targets normal rabbit IgG

View all literature mentions

Helios (M-20) (antibody)

RRID:AB_2124965

This polyclonal targets Helios (M-20)

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Histone H4ac (pan-acetyl) antibody (antibody)

RRID:AB_2687872

This polyclonal targets Histone H4ac (pan-acetyl)

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Histone H3ac (pan-acetyl) antibody (antibody)

RRID:AB_2687871

This polyclonal targets Histone H3ac (pan-acetyl)

View all literature mentions

Mouse Anti-Histone H3, acetyl (Lys4), trimethyl ChIPAb+ Monoclonal Antibody, Unconjugated (antibody)

RRID:AB_1977250

This monoclonal targets Histone H3, acetyl (Lys4), trimethyl

View all literature mentions

Histone H3K9me3 Antibody (antibody)

RRID:AB_2687870

This monoclonal targets H3K9me3

View all literature mentions

Rabbit Anti-Goat Rabbit anti-goat IgG-HRP Polyclonal, Hrp Conjugated (antibody)

RRID:AB_656964

This polyclonal targets Goat IgG

View all literature mentions

Anti-mouse IgG, HRP-linked Antibody (antibody)

RRID:AB_330924

This polyclonal targets IgG

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Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

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β-Actin (8H10D10) Mouse mAb (HRP Conjugate) (antibody)

RRID:AB_2566811

This monoclonal targets

View all literature mentions

BATF (D7C5) Rabbit mAb (antibody)

RRID:AB_11141425

This monoclonal targets BATF

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Alexa Fluor(R) 700 anti-mouse IL-2 (antibody)

RRID:AB_528931

This monoclonal targets IL-2

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Alexa Fluor(R) 647 anti-mouse IL-10 (antibody)

RRID:AB_493511

This monoclonal targets IL-10

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Peanut agglutinin (PNA) (antibody)

RRID:AB_2315097

This unknown targets

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Pacific Blue(TM) anti-MU/HU GL7 Antigen (T/B Cell Act. Marker) (antibody)

RRID:AB_2563292

This monoclonal targets GL7

View all literature mentions

PE/Cyanine5 anti-mouse CD19 (antibody)

RRID:AB_313645

This monoclonal targets CD19

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PE/Cyanine7 anti-mouse CD138 (Syndecan-1) (antibody)

RRID:AB_2562198

This monoclonal targets CD138

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Streptavidin-Allophycocyanin (antibody)

RRID:AB_10050396

This unknown targets Streptavidin-Allophycocyanin

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CXCR5 (antibody)

RRID:AB_394301

This monoclonal targets CXCR5

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Bcl-6 (antibody)

RRID:AB_10717126

This monoclonal targets Bcl-6

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GM-CSF Monoclonal Antibody (MP1-22E9), PE, eBioscience (antibody)

RRID:AB_466205

This monoclonal targets GM-CSF

View all literature mentions

PE/Cyanine7 anti-mouse TCR beta chain (antibody)

RRID:AB_893625

This monoclonal targets TCR beta chain

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Alexa Fluor(R) 647 anti-mouse IL-17F (antibody)

RRID:AB_10578083

This monoclonal targets IL-17F

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Glucose Transporter GLUT1 antibody [SPM498] (antibody)

RRID:AB_2190927

This monoclonal targets SLC2A1

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PE anti-mouse CD98 (4F2) (antibody)

RRID:AB_1186107

This monoclonal targets CD98

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PE/Cyanine7 anti-mouse CD71 (antibody)

RRID:AB_2203382

This monoclonal targets CD71

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CD278 (ICOS) Monoclonal Antibody (C398.4A), PE, eBioscience (antibody)

RRID:AB_466277

This monoclonal targets CD278 (ICOS)

View all literature mentions

Ki-67 Monoclonal Antibody (SolA15), PE-Cyanine7, eBioscience (antibody)

RRID:AB_11220070

This monoclonal targets Ki-67

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TCR V beta 6 Monoclonal Antibody (RR4-7), PerCP-eFluor™ 710, eBioscience (antibody)

RRID:AB_11150054

This monoclonal targets TCR V beta 6

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FITC anti-mouse TCR Valpha2 (antibody)

RRID:AB_1134188

This monoclonal targets TCR Valpha2

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Alexa Fluor(R) 700 anti-mouse CD45.2 (antibody)

RRID:AB_493731

This monoclonal targets CD45.2

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HELIOS Monoclonal Antibody (22F6), PE, eBioscience (antibody)

RRID:AB_2572758

This monoclonal targets HELIOS

View all literature mentions

PE anti-mouse CD226 (DNAM-1) (antibody)

RRID:AB_1186120

This monoclonal targets CD226

View all literature mentions

CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience (antibody)

RRID:AB_465863

This monoclonal targets CD137 (4-1BB)

View all literature mentions

PE anti-mouse CD357 (GITR) (antibody)

RRID:AB_1089132

This monoclonal targets CD357

View all literature mentions

CD69 Monoclonal Antibody (H1.2F3), PE, eBioscience (antibody)

RRID:AB_465732

This monoclonal targets CD69

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CD366 (TIM3) Monoclonal Antibody (8B.2C12), PE, eBioscience (antibody)

RRID:AB_465976

This monoclonal targets CD366 (TIM3)

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PE anti-mouse CD244.2 (2B4 B6 Alloantigen) (antibody)

RRID:AB_1626231

This monoclonal targets CD244.2

View all literature mentions

CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), PE, eBioscience (antibody)

RRID:AB_466089

This monoclonal targets CD274 (PD-L1, B7-H1)

View all literature mentions

APC anti-mouse CD223 (LAG-3) (antibody)

RRID:AB_10639935

This monoclonal targets CD223

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CD152 (CTLA-4) Monoclonal Antibody (UC10-4B9), APC, eBioscience (antibody)

RRID:AB_2016700

This monoclonal targets CD152 (CTLA-4)

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Alexa Fluor(R) 647 anti-mouse CD272 (BTLA) (antibody)

RRID:AB_10613297

This monoclonal targets CD272

View all literature mentions

PE anti-mouse FR4 (Folate Receptor 4) (antibody)

RRID:AB_1236541

This monoclonal targets FR4

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APC anti-mouse CD73 (antibody)

RRID:AB_11219400

This monoclonal targets CD73

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PE anti-mouse CD160 (antibody)

RRID:AB_10960743

This monoclonal targets CD160

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APC anti-mouse CD279 (PD-1) (antibody)

RRID:AB_2159183

This monoclonal targets CD279

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Alexa Fluor(R) 647 anti-human/mouse Granzyme B (antibody)

RRID:AB_2566333

This monoclonal targets Granzyme B

View all literature mentions

Perforin Monoclonal Antibody (eBioOMAK-D), PE, eBioscience (antibody)

RRID:AB_466243

This monoclonal targets Perforin

View all literature mentions

PE anti-mouse IL-4 (antibody)

RRID:AB_315318

This monoclonal targets IL-4

View all literature mentions

FOXP3 Monoclonal Antibody (FJK-16s), PE, eBioscience (antibody)

RRID:AB_465936

This monoclonal targets FOXP3

View all literature mentions

TNF alpha Monoclonal Antibody (MP6-XT22), PE, eBioscience (antibody)

RRID:AB_466199

This monoclonal targets TNF alpha

View all literature mentions

PE anti-mouse IL-17A (antibody)

RRID:AB_315464

This monoclonal targets IL-17A

View all literature mentions

PE anti-mouse IFN-gamma (antibody)

RRID:AB_315402

This monoclonal targets IFN-gamma

View all literature mentions

PE anti-mouse/human KLRG1 (MAFA) (antibody)

RRID:AB_10574313

This monoclonal targets KLRG1

View all literature mentions

CD25 Monoclonal Antibody (PC61.5), APC, eBioscience (antibody)

RRID:AB_469366

This monoclonal targets CD25

View all literature mentions

APC/Cyanine7 anti-mouse CD45.1 (antibody)

RRID:AB_313505

This monoclonal targets CD45.1

View all literature mentions

APC/Cyanine7 anti-mouse CD45 (antibody)

RRID:AB_312981

This monoclonal targets CD45

View all literature mentions

CD3e Monoclonal Antibody (145-2C11), PerCP-Cyanine5.5, eBioscience (antibody)

RRID:AB_1107000

This monoclonal targets CD3e

View all literature mentions

Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647 (antibody)

RRID:AB_2535864

This polyclonal secondary targets IgG (H+L)

View all literature mentions

Donkey Anti-Goat IgG (H+L) Antibody, Alexa Fluor 488 Conjugated (antibody)

RRID:AB_2534102

This unknown targets IgG (H+L)

View all literature mentions

IRF4-human (antibody)

RRID:AB_2127145

This polyclonal targets IRF4

View all literature mentions

CD44 Monoclonal Antibody (IM7), Alexa Fluor™ 700, eBioscience (antibody)

RRID:AB_494011

This monoclonal targets CD44

View all literature mentions

FITC anti-mouse CD62L (antibody)

RRID:AB_313093

This monoclonal targets CD62L

View all literature mentions

Pacific Blue(TM) anti-mouse CD8a (antibody)

RRID:AB_493425

This monoclonal targets CD8a

View all literature mentions

PE/Cyanine7 anti-mouse CD4 (antibody)

RRID:AB_312707

This monoclonal targets CD4

View all literature mentions

B6.Cg-Foxp3tm1.1Mal/J (organism)

RRID:IMSR_JAX:018628

Mus musculus with name B6.Cg-Foxp3tm1.1Mal/J from IMSR.

View all literature mentions

B6.SJL-Ptprca Pepc/BoyJ (organism)

RRID:IMSR_JAX:002014

Mus musculus with name B6.SJL-Ptprca Pepc/BoyJ from IMSR.

View all literature mentions

B6.Cg-Tg(Tcra.Tcrb)3Ayr/J (organism)

RRID:IMSR_JAX:005655

Mus musculus with name B6.Cg-Tg(Tcra.Tcrb)3Ayr/J from IMSR.

View all literature mentions

C57BL/6J (organism)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

View all literature mentions

B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ (organism)

RRID:IMSR_JAX:022071

Mus musculus with name B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ from IMSR.

View all literature mentions

B6.129S1-Irf4tm1Rdf/J (organism)

RRID:IMSR_JAX:009380

Mus musculus with name B6.129S1-Irf4tm1Rdf/J from IMSR.

View all literature mentions

Perforin Monoclonal Antibody (eBioOMAK-D), PE, eBioscience (antibody)

RRID:AB_466243

This monoclonal targets Perforin

View all literature mentions

FOXP3 Monoclonal Antibody (FJK-16s), PE, eBioscience (antibody)

RRID:AB_465936

This monoclonal targets FOXP3

View all literature mentions

PE anti-mouse IL-4 (antibody)

RRID:AB_315318

This monoclonal targets IL-4

View all literature mentions

PE anti-mouse CD160 (antibody)

RRID:AB_10960743

This monoclonal targets CD160

View all literature mentions

APC anti-mouse CD73 (antibody)

RRID:AB_11219400

This monoclonal targets CD73

View all literature mentions

PE anti-mouse FR4 (Folate Receptor 4) (antibody)

RRID:AB_1236541

This monoclonal targets FR4

View all literature mentions

Alexa Fluor(R) 647 anti-human/mouse Granzyme B (antibody)

RRID:AB_2566333

This monoclonal targets Granzyme B

View all literature mentions

APC anti-mouse CD279 (PD-1) (antibody)

RRID:AB_2159183

This monoclonal targets CD279

View all literature mentions

CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), PE, eBioscience (antibody)

RRID:AB_466089

This monoclonal targets CD274 (PD-L1, B7-H1)

View all literature mentions

APC anti-mouse CD223 (LAG-3) (antibody)

RRID:AB_10639935

This monoclonal targets CD223

View all literature mentions

PE anti-mouse CD244.2 (2B4 B6 Alloantigen) (antibody)

RRID:AB_1626231

This monoclonal targets CD244.2

View all literature mentions

Alexa Fluor(R) 647 anti-mouse CD272 (BTLA) (antibody)

RRID:AB_10613297

This monoclonal targets CD272

View all literature mentions

CD152 (CTLA-4) Monoclonal Antibody (UC10-4B9), APC, eBioscience (antibody)

RRID:AB_2016700

This monoclonal targets CD152 (CTLA-4)

View all literature mentions

PE anti-mouse CD357 (GITR) (antibody)

RRID:AB_1089132

This monoclonal targets CD357

View all literature mentions

CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience (antibody)

RRID:AB_465863

This monoclonal targets CD137 (4-1BB)

View all literature mentions

PE anti-mouse CD226 (DNAM-1) (antibody)

RRID:AB_1186120

This monoclonal targets CD226

View all literature mentions

CD366 (TIM3) Monoclonal Antibody (8B.2C12), PE, eBioscience (antibody)

RRID:AB_465976

This monoclonal targets CD366 (TIM3)

View all literature mentions

CD69 Monoclonal Antibody (H1.2F3), PE, eBioscience (antibody)

RRID:AB_465732

This monoclonal targets CD69

View all literature mentions

TCR V beta 6 Monoclonal Antibody (RR4-7), PerCP-eFluor™ 710, eBioscience (antibody)

RRID:AB_11150054

This monoclonal targets TCR V beta 6

View all literature mentions

FITC anti-mouse TCR Valpha2 (antibody)

RRID:AB_1134188

This monoclonal targets TCR Valpha2

View all literature mentions

Ki-67 Monoclonal Antibody (SolA15), PE-Cyanine7, eBioscience (antibody)

RRID:AB_11220070

This monoclonal targets Ki-67

View all literature mentions

Alexa Fluor(R) 700 anti-mouse CD45.2 (antibody)

RRID:AB_493731

This monoclonal targets CD45.2

View all literature mentions

HELIOS Monoclonal Antibody (22F6), PE, eBioscience (antibody)

RRID:AB_2572758

This monoclonal targets HELIOS

View all literature mentions

Alexa Fluor(R) 647 anti-mouse IL-17F (antibody)

RRID:AB_10578083

This monoclonal targets IL-17F

View all literature mentions

Glucose Transporter GLUT1 antibody [SPM498] (antibody)

RRID:AB_2190927

This monoclonal targets SLC2A1

View all literature mentions

PE anti-mouse CD98 (4F2) (antibody)

RRID:AB_1186107

This monoclonal targets CD98

View all literature mentions

CD278 (ICOS) Monoclonal Antibody (C398.4A), PE, eBioscience (antibody)

RRID:AB_466277

This monoclonal targets CD278 (ICOS)

View all literature mentions

PE/Cyanine7 anti-mouse CD71 (antibody)

RRID:AB_2203382

This monoclonal targets CD71

View all literature mentions

PE/Cyanine7 anti-mouse TCR beta chain (antibody)

RRID:AB_893625

This monoclonal targets TCR beta chain

View all literature mentions

GM-CSF Monoclonal Antibody (MP1-22E9), PE, eBioscience (antibody)

RRID:AB_466205

This monoclonal targets GM-CSF

View all literature mentions

Streptavidin-Allophycocyanin (antibody)

RRID:AB_10050396

This unknown targets Streptavidin-Allophycocyanin

View all literature mentions

PE/Cyanine5 anti-mouse CD19 (antibody)

RRID:AB_313645

This monoclonal targets CD19

View all literature mentions

CXCR5 (antibody)

RRID:AB_394301

This monoclonal targets CXCR5

View all literature mentions

Bcl-6 (antibody)

RRID:AB_10717126

This monoclonal targets Bcl-6

View all literature mentions

B6.Cg-Foxp3tm1.1Mal/J (organism)

RRID:IMSR_JAX:018628

Mus musculus with name B6.Cg-Foxp3tm1.1Mal/J from IMSR.

View all literature mentions

B6.Cg-Tg(Tcra.Tcrb)3Ayr/J (organism)

RRID:IMSR_JAX:005655

Mus musculus with name B6.Cg-Tg(Tcra.Tcrb)3Ayr/J from IMSR.

View all literature mentions

B6.SJL-Ptprca Pepc/BoyJ (organism)

RRID:IMSR_JAX:002014

Mus musculus with name B6.SJL-Ptprca Pepc/BoyJ from IMSR.

View all literature mentions

B6.129S7-Rag1tm1Mom/J (organism)

RRID:IMSR_JAX:002216

Mus musculus with name B6.129S7-Rag1tm1Mom/J from IMSR.

View all literature mentions

B6.129S1-Irf4tm1Rdf/J (organism)

RRID:IMSR_JAX:009380

Mus musculus with name B6.129S1-Irf4tm1Rdf/J from IMSR.

View all literature mentions

B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ (organism)

RRID:IMSR_JAX:022071

Mus musculus with name B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ from IMSR.

View all literature mentions

BALB/cJ (organism)

RRID:IMSR_JAX:000651

Mus musculus with name BALB/cJ from IMSR.

View all literature mentions

C57BL/6J (organism)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

View all literature mentions

LEAF™ Purified anti-mouse CD3? (antibody)

RRID:AB_312679

This monoclonal targets CD3epsilon

View all literature mentions

PE anti-mouse CD3epsilon (antibody)

RRID:AB_312673

This monoclonal targets CD3epsilon

View all literature mentions

rat IgG2b I sotype control (antibody)

RRID:AB_1107780

This isotype control targets KLH

View all literature mentions

InVivoPlus anti-mouse CD25 (IL-2Rα) (antibody)

RRID:AB_1107619

This monoclonal targets CD25 (IL-2Rα)

View all literature mentions

InVivoPlus anti-mouse CD8α (antibody)

RRID:AB_1107671

This monoclonal targets CD8α

View all literature mentions

anti-mouse CD4 (antibody)

RRID:AB_1107636

This monoclonal targets CD4

View all literature mentions

InVivoPlus anti-mouse CTLA-4 (CD152) (antibody)

RRID:AB_10949609

This monoclonal targets CTLA-4 (CD152)

View all literature mentions

InVivoPlus anti-mouse PD-L1 (B7-H1) (antibody)

RRID:AB_10949073

This monoclonal targets PD-L1 (B7-H1)

View all literature mentions

normal rabbit IgG (antibody)

RRID:AB_737197

This unknown targets normal rabbit IgG

View all literature mentions

Helios (M-20) (antibody)

RRID:AB_2124965

This polyclonal targets Helios (M-20)

View all literature mentions

Histone H4ac (pan-acetyl) antibody (antibody)

RRID:AB_2687872

This polyclonal targets Histone H4ac (pan-acetyl)

View all literature mentions

Histone H3ac (pan-acetyl) antibody (antibody)

RRID:AB_2687871

This polyclonal targets Histone H3ac (pan-acetyl)

View all literature mentions

Mouse Anti-Histone H3, acetyl (Lys4), trimethyl ChIPAb+ Monoclonal Antibody, Unconjugated (antibody)

RRID:AB_1977250

This monoclonal targets Histone H3, acetyl (Lys4), trimethyl

View all literature mentions

Histone H3K9me3 Antibody (antibody)

RRID:AB_2687870

This monoclonal targets H3K9me3

View all literature mentions

Rabbit Anti-Goat Rabbit anti-goat IgG-HRP Polyclonal, Hrp Conjugated (antibody)

RRID:AB_656964

This polyclonal targets Goat IgG

View all literature mentions

Anti-mouse IgG, HRP-linked Antibody (antibody)

RRID:AB_330924

This polyclonal targets IgG

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

β-Actin (8H10D10) Mouse mAb (HRP Conjugate) (antibody)

RRID:AB_2566811

This monoclonal targets

View all literature mentions

BATF (D7C5) Rabbit mAb (antibody)

RRID:AB_11141425

This monoclonal targets BATF

View all literature mentions

IL-13 Monoclonal Antibody (eBio13A), PerCP-eFluor™ 710, eBioscience (antibody)

RRID:AB_11218496

This monoclonal targets IL-13

View all literature mentions

Alexa Fluor(R) 700 anti-mouse IL-2 (antibody)

RRID:AB_528931

This monoclonal targets IL-2

View all literature mentions

Alexa Fluor(R) 647 anti-mouse IL-10 (antibody)

RRID:AB_493511

This monoclonal targets IL-10

View all literature mentions

Peanut agglutinin (PNA) (antibody)

RRID:AB_2315097

This unknown targets

View all literature mentions

Pacific Blue(TM) anti-MU/HU GL7 Antigen (T/B Cell Act. Marker) (antibody)

RRID:AB_2563292

This monoclonal targets GL7

View all literature mentions

PE/Cyanine7 anti-mouse CD138 (Syndecan-1) (antibody)

RRID:AB_2562198

This monoclonal targets CD138

View all literature mentions

TNF alpha Monoclonal Antibody (MP6-XT22), PE, eBioscience (antibody)

RRID:AB_466199

This monoclonal targets TNF alpha

View all literature mentions

PE anti-mouse IL-17A (antibody)

RRID:AB_315464

This monoclonal targets IL-17A

View all literature mentions

PE anti-mouse IFN-gamma (antibody)

RRID:AB_315402

This monoclonal targets IFN-gamma

View all literature mentions

PE anti-mouse/human KLRG1 (MAFA) (antibody)

RRID:AB_10574313

This monoclonal targets KLRG1

View all literature mentions

CD25 Monoclonal Antibody (PC61.5), APC, eBioscience (antibody)

RRID:AB_469366

This monoclonal targets CD25

View all literature mentions

CD44 Monoclonal Antibody (IM7), Alexa Fluor™ 700, eBioscience (antibody)

RRID:AB_494011

This monoclonal targets CD44

View all literature mentions

FITC anti-mouse CD62L (antibody)

RRID:AB_313093

This monoclonal targets CD62L

View all literature mentions

Pacific Blue(TM) anti-mouse CD8a (antibody)

RRID:AB_493425

This monoclonal targets CD8a

View all literature mentions

PE/Cyanine7 anti-mouse CD4 (antibody)

RRID:AB_312707

This monoclonal targets CD4

View all literature mentions

APC/Cyanine7 anti-mouse CD45.1 (antibody)

RRID:AB_313505

This monoclonal targets CD45.1

View all literature mentions

APC/Cyanine7 anti-mouse CD45 (antibody)

RRID:AB_312981

This monoclonal targets CD45

View all literature mentions

CD3e Monoclonal Antibody (145-2C11), PerCP-Cyanine5.5, eBioscience (antibody)

RRID:AB_1107000

This monoclonal targets CD3e

View all literature mentions

Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647 (antibody)

RRID:AB_2535864

This polyclonal secondary targets IgG (H+L)

View all literature mentions

Donkey Anti-Goat IgG (H+L) Antibody, Alexa Fluor 488 Conjugated (antibody)

RRID:AB_2534102

This unknown targets IgG (H+L)

View all literature mentions

IRF4-human (antibody)

RRID:AB_2127145

This polyclonal targets IRF4

View all literature mentions

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