Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Sonic Hedgehog and WNT Signaling Promote Adrenal Gland Regeneration in Male Mice.

Endocrinology | 2018

The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid replacement that often prolongs the ultimate return of endogenous adrenocortical function. Underlying this functional recovery is anatomic regeneration, the cellular and molecular mechanisms of which are poorly understood. Investigating the lineage contribution of cortical Sonic hedgehog (Shh)+ progenitor cells and the SHH-responsive capsular Gli1+ cells to the regenerating adrenal cortex, we observed a spatially and temporally bimodal contribution of both cell types to adrenocortical regeneration following cessation of glucocorticoid treatment. First, an early repopulation of the cortex is defined by a marked delamination and expansion of capsular Gli1+ cells, recapitulating the establishment of the capsular-cortical homeostatic niche during embryonic development. This rapid repopulation is promptly cleared from the cortical compartment only to be supplanted by repopulating cortical cells derived from the resident long-term-retained zona glomerulosa Shh+ progenitors. Pharmacologic and genetic dissection of SHH signaling further defines an SHH-dependent activation of WNT signaling that supports regeneration of the cortex following long-term glucocorticoid therapy. We define the signaling and lineage relationships that underlie the regeneration process.

Pubmed ID: 29211850 RIS Download

Mesh terms: Adrenal Cortex | Adrenal Glands | Animals | Female | Glucocorticoids | Hedgehog Proteins | Male | Mice | Mice, Inbred C57BL | Regeneration | Signal Transduction | Stem Cells | Wnt4 Protein | Zinc Finger Protein GLI1 | Zona Glomerulosa

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


PCNA (PC10) Mouse mAb antibody (antibody)

RRID:AB_2160343

This monoclonal antibody targets PCNA

View all literature mentions

Ki-67 antibody (antibody)

RRID:AB_393778

This monoclonal antibody targets Ki-67

View all literature mentions

Dylight 549 Goat-α-Rabbit IgG (H+L) antibody (antibody)

RRID:AB_2493180

This polyclonal antibody targets Rabbit IgG (H+L)

View all literature mentions

CYP11B2 antibody (antibody)

RRID:AB_2716717

This polyclonal antibody targets CYP11B2

View all literature mentions

Sf1 antibody (antibody)

RRID:AB_2716716

This unknown targets Sf1

View all literature mentions

CYP11B1 antibody (antibody)

RRID:AB_2716718

This monoclonal antibody targets CYP11B1

View all literature mentions

DyLight 549-ChromPure Chicken IgY (IgG), whole molecule antibody (antibody)

RRID:AB_2336975

This unknown targets Chicken IgY (IgG), whole molecule

View all literature mentions

Anti-GFP antibody (antibody)

RRID:AB_300798

This polyclonal antibody targets GFP

View all literature mentions