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Monoclonal antibodies (mAbs) can destroy tumors by recruiting effectors such as myeloid cells, or targeting immunomodulatory receptors to promote cytotoxic T cell responses. Here, we examined the therapeutic potential of combining a direct tumor-targeting mAb, anti-CD20, with an extended panel of immunomodulatory mAbs. Only the anti-CD27/CD20 combination provided cures. This was apparent in multiple lymphoma models, including huCD27 transgenic mice using the anti-huCD27, varlilumab. Detailed mechanistic analysis using single-cell RNA sequencing demonstrated that anti-CD27 stimulated CD8+ T and natural killer cells to release myeloid chemo-attractants and interferon gamma, to elicit myeloid infiltration and macrophage activation. This study demonstrates the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Pubmed ID: 29198913 RIS Download
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Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsA cloud-based platform which allows users to analyze, visualize, and archive multiparamter cytometry data for single-cell biology. Multiple single-cell data sets can be analyzed and visualized simultaneously with a variety of graphics, inlcuding Sunburst, SPADE, and viSNE. Users can store and back up related data such as protocols, microscopy images, and presentations and collaborate and share analysis and data sets with other Cytobank users. Cytobank also provides a variety of services and training sessions to assist with experiment workflow.
View all literature mentionsToppGene Suite is a one-stop portal for gene list enrichment analysis and candidate gene prioritization based on functional annotations and protein interactions network. ToppGene Suite is a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome. Functional annotation-based disease candidate gene prioritization uses a fuzzy-based similarity measure to compute the similarity between any two genes based on semantic annotations. The similarity scores from individual features are combined into an overall score using statistical meta-analysis.
View all literature mentionsAn Organization portal, Antibody supplier, Service resource,
View all literature mentionsBioconductor software package for Empirical analysis of Digital Gene Expression data in R. Used for differential expression analysis of RNA-seq and digital gene expression data with biological replication.
View all literature mentionslaboratory mouse with name BALB/cAnNCrl from MGI.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsCell line BCBL-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets IFNγ
View all literature mentionsThis monoclonal targets GITR
View all literature mentionsThis monoclonal targets CTLA-4 (CD152)
View all literature mentionsThis monoclonal targets PD-1 (CD279)
View all literature mentionsThis monoclonal targets PD-L1 (B7-H1)
View all literature mentionsThis monoclonal targets
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets CD86 (B7-2)
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Mouse F4/80 ANTIGEN
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD49b (Integrin alpha 2)
View all literature mentionsThis monoclonal targets CD335 (NKp46)
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
View all literature mentionsMus musculus with name BALB/cAnNCrl from IMSR.
View all literature mentionsMus musculus with name CB17/Icr-Prkdcscid/IcrIcoCrl from IMSR.
View all literature mentionsMus musculus with name BALB/cAnNCrl from IMSR.
View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
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