Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Publication

Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner.

Journal of neuroinflammation | 2017

Spinal cord astrocyte swelling is an important component to spinal cord edema and is associated with poor functional recovery as well as therapeutic resistance after spinal cord injury (SCI). High mobility group box-1 (HMGB1) is a mediator of inflammatory responses in the central nervous system and plays a critical role after SCI. Given this, we sought to identify both the role and underlying mechanisms of HMGB1 in cellular swelling and aquaporin 4 (AQP4) expression in cultured rat spinal cord astrocytes after oxygen-glucose deprivation/reoxygenation (OGD/R).

Pubmed ID: 29178911 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

Antibodies used in this publication

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

PeproTech (tool)

RRID:SCR_006802

An Antibody supplier

View all literature mentions

SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

View all literature mentions

FITC labeled goat anti-mouse IgG (antibody)

RRID:AB_2716306

This unknown targets IgG

View all literature mentions

Goat anti-rabbit IgG-CY3 (antibody)

RRID:AB_2716305

This unknown targets IgG

View all literature mentions

Goat anti-mouse IgG-HRP (antibody)

RRID:AB_2716555

This polyclonal targets IgG h+l

View all literature mentions

Goat anti-rabbit IgG-HRP (antibody)

RRID:AB_2716554

This polyclonal targets IgG h+l

View all literature mentions

Anti-S100B Antibody (monoclonal, SH-B1) (antibody)

RRID:AB_2716291

This monoclonal targets S100-B

View all literature mentions

Histone H3 Mouse Monoclonal Antibody (antibody)

RRID:AB_2715593

This monoclonal targets Histone H3 protein

View all literature mentions

GAPDH Mouse Monoclonal Antibody (antibody)

RRID:AB_2715590

This monoclonal targets GFAP protein

View all literature mentions

NF-κB p65 (C22B4) Rabbit monoclonal Antibody (antibody)

RRID:AB_823578

This monoclonal targets NF-κB p65

View all literature mentions

Phospho-I-kappa-B-alpha (Ser32/36) (5A5) Mouse monoclonal Antibody (antibody)

RRID:AB_2267145

This monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)

View all literature mentions

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (antibody)

RRID:AB_390781

This monoclonal targets IkappaB-alpha

View all literature mentions

MyD88 antibody (antibody)

RRID:AB_11156885

This polyclonal targets MyD88 antibody

View all literature mentions

TLR4 Antibody (antibody)

RRID:AB_2716293

This polyclonal targets TLR4

View all literature mentions

Mouse Anti-TLR4 Monoclonal, Fitc Conjugated, Clone 76b357.1 (antibody)

RRID:AB_839000

This monoclonal targets TLR4

View all literature mentions

Rabbit Anti-Aquaporin 4 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_955676

This polyclonal targets Aquaporin 4

View all literature mentions

HMGB1 antibody - ChIP Grade (antibody)

RRID:AB_444360

This polyclonal targets HMGB1 antibody - ChIP Grade

View all literature mentions

Quantity One 1-D Analysis Software (software resource)

RRID:SCR_014280

Software used for Bio-Rad imaging systems to acquire, quantitate, and analyze a variety of data. The software allows automatic configuration of imaging systems with appropriate filters, lasers, LEDs, and other illumination sources. It also contains tools for automated analysis of tests and assays such as 1-D electrophoretic gels, western blots, and colony counts.

View all literature mentions