Eukaryotic translation initiation factor 4G (EIF4G) is an important scaffold protein in the translation initiation complex. In mice, mutation of the Eif4g3 gene causes male infertility, with arrest of meiosis at the end of meiotic prophase. This study documents features of the developmental expression and subcellular localization of EIF4G3 that might contribute to its highly specific role in meiosis and spermatogenesis. Quite unexpectedly, EIF4G3 is located in the nucleus of spermatocytes, where it is highly enriched in the XY body, the chromatin domain formed by the transcriptionally inactive sex chromosomes. Moreover, many other, but not all, translation-related proteins are also localized in the XY body. These unanticipated observations implicate roles for the XY body in controlling mRNA metabolism and/or "poising" protein translation complexes before the meiotic division phase in spermatocytes.
Pubmed ID: 29161344 RIS Download
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This polyclonal targets Human eIF4A3
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View all literature mentionsThis polyclonal targets TUBG1, TUBG2
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis monoclonal targets Puromycin from Streptomyces alboniger
View all literature mentionsThis polyclonal targets Human EIF4EBP1, phospho (Ser111)
View all literature mentionsThis polyclonal targets Phospho-4E-BP1 (Thr70)
View all literature mentionsThis polyclonal targets Phospho-4E-BP1 (Ser65)
View all literature mentionsThis polyclonal targets Chk2 (phospho T383)
View all literature mentionsThis polyclonal targets Phospho-Chk1 (Ser345)
View all literature mentionsThis polyclonal targets CDK3
View all literature mentionsThis monoclonal targets Phospho-CDK1 (Tyr15)
View all literature mentionsThis polyclonal targets HSPA2
View all literature mentionsThis polyclonal targets Translin
View all literature mentionsThis polyclonal targets Human Musashi-1
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View all literature mentionsThis unknown targets BOLL
View all literature mentionsThis polyclonal targets MNK2
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View all literature mentionsThis polyclonal targets EIF2C4
View all literature mentionsThis polyclonal targets EIF4EBP1
View all literature mentionsThis polyclonal targets RPL28
View all literature mentionsThis polyclonal targets Frizzled 7 antibody
View all literature mentionsThis monoclonal targets RPL10A
View all literature mentionsThis polyclonal targets RPS13 antibody
View all literature mentionsThis monoclonal targets S6
View all literature mentionsThis unknown targets RPS3
View all literature mentionsThis monoclonal targets Histone H2A.X pSer139
View all literature mentionsThis polyclonal targets EIF4A2
View all literature mentionsThis monoclonal targets eIF4A1
View all literature mentionsThis polyclonal targets EIF4E3
View all literature mentionsThis monoclonal targets eIF4E2 (YB-18)
View all literature mentionsThis monoclonal targets eIF4E
View all literature mentionsThis unknown targets eIF4G3
View all literature mentionsThis unknown targets eIF4G3/eIF4GII
View all literature mentionsThis monoclonal targets eIF4G2/p97 (D88B6) XP Rabbit mAb
View all literature mentionsThis monoclonal targets eIF4GI (D6A6) Rabbit mAb
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal targets TUBG1, TUBG2
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis monoclonal targets Puromycin from Streptomyces alboniger
View all literature mentionsThis polyclonal targets Human EIF4EBP1, phospho (Ser111)
View all literature mentionsThis polyclonal targets Phospho-4E-BP1 (Thr70)
View all literature mentionsThis polyclonal targets Phospho-4E-BP1 (Ser65)
View all literature mentionsThis polyclonal targets Chk2 (phospho T383)
View all literature mentionsThis polyclonal targets Phospho-Chk1 (Ser345)
View all literature mentionsThis polyclonal targets CDK3
View all literature mentionsThis monoclonal targets Phospho-CDK1 (Tyr15)
View all literature mentionsThis polyclonal targets HSPA2
View all literature mentionsThis polyclonal targets Translin
View all literature mentionsThis polyclonal targets Human Musashi-1
View all literature mentionsThis polyclonal targets HuR
View all literature mentionsThis unknown targets BOLL
View all literature mentionsThis polyclonal targets MNK2
View all literature mentionsThis monoclonal targets Mnk1
View all literature mentionsThis polyclonal targets EIF2C4
View all literature mentionsThis polyclonal targets EIF4EBP1
View all literature mentionsThis polyclonal targets RPL28
View all literature mentionsThis polyclonal targets Frizzled 7 antibody
View all literature mentionsThis monoclonal targets RPL10A
View all literature mentionsThis polyclonal targets RPS13 antibody
View all literature mentionsThis monoclonal targets S6
View all literature mentionsThis unknown targets RPS3
View all literature mentionsThis monoclonal targets Histone H2A.X pSer139
View all literature mentionsThis polyclonal targets EIF4A2
View all literature mentionsThis monoclonal targets eIF4A1
View all literature mentionsThis polyclonal targets EIF4E3
View all literature mentionsThis monoclonal targets eIF4E2 (YB-18)
View all literature mentionsThis monoclonal targets eIF4E
View all literature mentionsThis unknown targets eIF4G3
View all literature mentionsThis unknown targets eIF4G3/eIF4GII
View all literature mentionsThis monoclonal targets eIF4G2/p97 (D88B6) XP Rabbit mAb
View all literature mentionsThis monoclonal targets eIF4GI (D6A6) Rabbit mAb
View all literature mentionsThis polyclonal targets Human eIF4A3
View all literature mentionsThis polyclonal targets Human eIF4A3
View all literature mentionsThis polyclonal targets Human eIF4A3
View all literature mentionsThis polyclonal targets Human eIF4A3
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