Bruton's tyrosine kinase (Btk) is a non-receptor tyrosine kinase involved in the activation of signalling pathways responsible for cell maturation and viability. Btk has previously been reported to be overexpressed in colon cancers. This kind of cancer is often accompanied by anaemia, which is treated with an erythropoietin supplement. The goal of the present study was to assess the effects of combination therapy with erythropoietin β (Epo) and LFM-A13 (Btk inhibitor) on colon cancer in in vitro and in vivo models.
Pubmed ID: 29160911 RIS Download
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Portal and searchable database of pharmacological information. Information is presented at two levels, the initial view or landing pages for each target family provide expert-curated overviews of the key properties and the available selective ligands and tool compounds. For selected targets, more detailed introductory chapters for each family are available along with curated information on the pharmacological, physiological, structural, genetic and pathophysiogical properties of each target.
View all literature mentionsThis polyclonal targets AKT3
View all literature mentionsThis polyclonal targets AKT1, AKT3
View all literature mentionsThis polyclonal targets Mouse IgG (whole molecule)-FITC antibody produced in goat
View all literature mentionsThis monoclonal targets EpoR (D-5)
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets IgG Rabbit
View all literature mentionsThis monoclonal targets Akt1
View all literature mentionsThis unknown targets Phospho-Btk (Tyr551)
View all literature mentionsThis monoclonal targets Human EpoR, phospho (Tyr485)
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets gamma-Tubulin antibody produced in mouse
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis unknown targets Rabbit IgG, whole molecule
View all literature mentionsThis polyclonal targets EPOR
View all literature mentionsThis polyclonal targets Rabbit IgG (whole molecule)-Alkaline Phosphatase antibody produced in goat
View all literature mentionsThis unknown targets Mouse IgG, whole molecule
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets PLK-1 Phospho Thr210
View all literature mentionsThis monoclonal targets Human Polo-Like Kinase (PLK) (PLK1)
View all literature mentionsThis polyclonal targets Caspase 3
View all literature mentionsThis polyclonal targets Caspase-3
View all literature mentionsThis monoclonal targets Human Phospho-Erythropoietin R (Y426) MAb (Clone 690710)
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
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Mus musculus with name STOCK Ces1ce Foxn1
Cell line HT-29 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line DLD-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 12,2023. Matlab code for two-factor (location and year) analysis-of-variance model for the calculation of climate anomalies, in which the reference interval is specified as the full length of the dataset. This scheme avoids the affects of shorter (e.g. 1961-1990) reference intervals on the temporal evolution of the spatial standard deviation of climate anomalies. Data files provided.
View all literature mentionsA tool to design target-specific primers for polymerase chain reaction (PCR). It uses Primer3 to design PCR primers and then uses BLAST and global alignment algorithm to screen primers against user-selected database in order to avoid primer pairs (all combinations including forward-reverse primer pair, forward-forward as well as reverse-reverse pairs) that can cause non-specific amplifications.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets IgG Rabbit
View all literature mentionsThis monoclonal targets Akt1
View all literature mentionsThis unknown targets Phospho-Btk (Tyr551)
View all literature mentionsThis monoclonal targets Human EpoR, phospho (Tyr485)
View all literature mentions
Mus musculus with name STOCK Ces1ce Foxn1
This unknown targets
View all literature mentionsThis monoclonal targets gamma-Tubulin antibody produced in mouse
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis unknown targets Rabbit IgG, whole molecule
View all literature mentionsThis polyclonal targets EPOR
View all literature mentionsThis polyclonal targets Rabbit IgG (whole molecule)-Alkaline Phosphatase antibody produced in goat
View all literature mentionsThis unknown targets Mouse IgG, whole molecule
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets PLK-1 Phospho Thr210
View all literature mentionsThis monoclonal targets Human Polo-Like Kinase (PLK) (PLK1)
View all literature mentionsThis polyclonal targets Caspase 3
View all literature mentionsThis polyclonal targets Caspase-3
View all literature mentionsThis monoclonal targets Human Phospho-Erythropoietin R (Y426) MAb (Clone 690710)
View all literature mentionsCell line HT-29 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line DLD-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal targets AKT3
View all literature mentionsThis polyclonal targets AKT1, AKT3
View all literature mentionsThis monoclonal targets EpoR (D-5)
View all literature mentionsThis polyclonal targets Mouse IgG (whole molecule)-FITC antibody produced in goat
View all literature mentionsThis polyclonal targets AKT3
View all literature mentionsThis polyclonal targets AKT1, AKT3
View all literature mentionsThis monoclonal targets EpoR (D-5)
View all literature mentionsThis polyclonal targets AKT3
View all literature mentionsThis polyclonal targets Mouse IgG (whole molecule)-FITC antibody produced in goat
View all literature mentionsThis polyclonal targets Mouse IgG (whole molecule)-FITC antibody produced in goat
View all literature mentionsThis polyclonal targets AKT1, AKT3
View all literature mentionsThis monoclonal targets EpoR (D-5)
View all literature mentionsThis polyclonal targets Mouse IgG (whole molecule)-FITC antibody produced in goat
View all literature mentionsThis polyclonal targets AKT3
View all literature mentionsThis polyclonal targets AKT1, AKT3
View all literature mentionsThis monoclonal targets EpoR (D-5)
View all literature mentions