The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates in the regulation of LHb function. Here, we provide evidence that the LPO exerts bivalent control over the LHb through the convergent transmission of LPO glutamate and γ-aminobutyric acid (GABA) onto single LHb neurons. In vivo, both LPO-glutamatergic and LPO-GABAergic inputs to the LHb are activated by aversive stimuli, and their predictive cues yet produce opposing behaviors when stimulated independently. These results support a model wherein the balanced response of converging LPO-glutamate and LPO-GABA are necessary for a normal response to noxious stimuli, and an imbalance in LPO→LHb glutamate or GABA results in the type of aberrant processing that may underlie mental disorders.
Pubmed ID: 29141211 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This monoclonal targets mCherry
View all literature mentionsThis polyclonal targets mouse VGAT, 31-112 aa(BC052020)
View all literature mentionsThis polyclonal targets Fluoro-gold
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis unknown targets Digoxigenin
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentions