Duchenne muscular dystrophy (DMD) is caused by abnormalities in the dystrophin gene and is clinically characterised by childhood muscle degeneration and cardiomyopathy. We produced an induced pluripotent stem cell line from a DMD patient's dermal fibroblasts by electroporation with episomal vectors containing: hL-MYC, hLIN28, hSOX2, hKLF4, hOCT3/4. The resultant DMD iPSC line (CCMi001DMD-A-3) displayed iPSC morphology, expressed pluripotency markers, possessed trilineage differentiation potential and was karyotypically normal. MLPA analyses performed on DNA extracted from CCMi001DMD-A-3 showed a deletion of exons 49 and 50 (CCMi001DMD-A-3, ∆49, ∆50).
Pubmed ID: 29127875 RIS Download
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This unknown targets
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal secondary targets IgG2a
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis polyclonal targets Dystrophin antibody
View all literature mentionsThis monoclonal targets Acta2
View all literature mentionsThis monoclonal targets residues surrounding Pro272 of human Sox17 protein
View all literature mentionsThis monoclonal targets aa 1464-1614 of human nestin
View all literature mentionsThis polyclonal targets sox2
View all literature mentionsThis polyclonal targets Nanog
View all literature mentionsThis monoclonal targets SSEA4 antibody [MC813] - Embryonic Stem Cell Marker
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