Searching across hundreds of databases
Staphylococcus aureus commonly colonizes the epidermis, but the mechanisms by which the host senses virulent, but not commensal, S. aureus to trigger inflammation remain unclear. Using a murine epicutaneous infection model, we found that S. aureus-expressed phenol-soluble modulin (PSM)α, a group of secreted virulence peptides, is required to trigger cutaneous inflammation. PSMα induces the release of keratinocyte IL-1α and IL-36α, and signaling via IL-1R and IL-36R was required for induction of the pro-inflammatory cytokine IL-17. The levels of released IL-1α and IL-36α, as well as IL-17 production by γδ T cells and ILC3 and neutrophil infiltration to the site of infection, were greatly reduced in mice with total or keratinocyte-specific deletion of the IL-1R and IL-36R signaling adaptor Myd88. Further, Il17a-/-f-/- mice showed blunted S. aureus-induced inflammation. Thus, keratinocyte Myd88 signaling in response to S. aureus PSMα drives an IL-17-mediated skin inflammatory response to epicutaneous S. aureus infection.
Pubmed ID: 29120744 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
A commercial graphing software company that offers scientific software for statistical analyses, curve fitting and data analysis. It offers four programs: Prism, InStat, StatMate and QuickCalcs.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis monoclonal targets IL-22
View all literature mentionsThis monoclonal targets TCR beta chain
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets IL-17F
View all literature mentionsThis monoclonal targets IL-1alpha
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets GM-CSF
View all literature mentionsThis monoclonal targets CD90.2 (Thy-1.2)
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets Goat IgG (H+L)
View all literature mentionsThis isotype control targets KLH
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets Thy1
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsThis monoclonal targets Staphylococcus aureus antibody [704]
View all literature mentionsThis polyclonal targets Mouse IL-1F6 / FIL1 epsilon, Interleukin 1F6
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis monoclonal targets IL-1α
View all literature mentionsMus musculus with name B6.129P2-Tcrdtm1Mom/J from IMSR.
View all literature mentionsMus musculus with name B6N.Cg-Tg(KRT14-cre)1Amc/J from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsMus musculus with name B6.129S7-Il1r1tm1Imx/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
