Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor.

PLoS genetics | Nov 21, 2017

The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. Here, we show that these sex differences emerge during the first 10 postnatal days, precisely at a stage when a late wave of oligodendrocyte progenitor cells arises and starts differentiating. Androgen levels, analyzed by gas chromatography/tandem-mass spectrometry, were higher in males than in females during this period. Treating male pups with flutamide, an androgen receptor (AR) antagonist, or female pups with 5α-dihydrotestosterone (5α-DHT), revealed the importance of postnatal androgens in masculinizing myelin and their persistent effect into adulthood. A key role of the brain AR in establishing the sexual phenotype of myelin was demonstrated by its conditional deletion. Our results uncover a new persistent effect of postnatal AR signaling, with implications for neurodevelopmental disorders and sex differences in multiple sclerosis.

Pubmed ID: 29107990 RIS Download

Mesh terms: Androgen Receptor Antagonists | Androgens | Animals | Animals, Newborn | Brain | Dihydrotestosterone | Female | Flutamide | Male | Mice | Mice, Inbred C57BL | Myelin Sheath | Receptors, Androgen | Sex Differentiation

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Thermo Fisher Scientific

Commercial vendor and service provider of laboratory reagents and antibodies.

tool

View all literature mentions

Adobe Illustrator

Vector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.

tool

View all literature mentions

Graphpad Prism

Statistical software package for data analysis, hypothesis testing, and modeling. The software can capable perform mathematical calculations (including biostatistics) and graphical plotting such as curve fitting (nonlinear regression) and scientific graphing.

tool

View all literature mentions

LSM Image Examiner

Software used to compile images obtained from the Zeiss LSM 510 confocal microscope. The browser can be used for general image archiving and handling and interactive measurement in labs and workgroups. Features include orthogonal sectioning, 3D cut function, 3D view with calculation of single projections, and interactive measurement functions in the overlay dialog, such as scale bar, distance, and area.

tool

View all literature mentions

ImageJ

It is an open source image processing Java program designed for scientific multidimensional images. This open platform for scientific image analysis is used in life sciences. Image J has been transformed to ImageJ2 application. This new application improves ImageJ data engine to be sufficient to analyze modern datasets and makes the addition of new functionality possible and provides a framework for interoperability between a plethora of external image visualization and analysis programs. ImageJ2 strengthens ImageJ’s utility by: 1) generalizing the ImageJ data model; 2) introducing a robust architecture instrumental in building bridges across a range of other image processing tools; 3) remaining open source and cross-platform with permissive licensing, enabling continued widespread adoption and extension; 4) building on the huge collection of existing ImageJ plugins while enabling the creation of new plugins with more powerful features; and 5) leveraging a correspondingly large and diverse community to foster a collaborative and interdisciplinary project that facilitates the collective advancement of science.

tool

View all literature mentions