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The midbrain is an important subcortical area involved in distinct functions such as multimodal integration, movement initiation, bottom-up, and top-down attention. Our group is particularly interested in cellular computation of multisensory integration. We focus on the visual part of the avian midbrain, the optic tectum (TeO, counterpart to mammalian superior colliculus). This area has a layered structure with the great advantage of distinct input and output regions. In chicken, the TeO is organized in 15 layers where visual input targets the superficial layers while auditory input terminates in deeper layers. One specific cell type, the Shepherd's crook neuron (SCN), extends dendrites in both input regions. The characteristic feature of these neurons is the axon origin at the apical dendrite. The molecular identity of this characteristic region and thus, the site of action potential generation are of particular importance to understand signal flow and cellular computation in this neuron. We present immunohistochemical data of structural proteins (NF200, Ankyrin G, and Myelin) and ion channels (Pan-Nav , Nav 1.6, and Kv 3.1b). NF200 is strongly expressed in the axon. Ankyrin G is mainly expressed at the axon initial segment (AIS). Myelination starts after the AIS as well as the distribution of Nav channels on the axon. The subtype Nav 1.6 has a high density in this region. Kv 3.1b is restricted to the soma, the primary neurite and the axon branch. The distribution of functional molecules in SCNs provides insight into the information flow and the integration of sensory modalities in the TeO of the avian midbrain.
Pubmed ID: 29055053 RIS Download
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This unknown targets SCN2A (NaV1.2) Channel
View all literature mentionsThis unknown targets NaV1.6 (SCN8A) Channel
View all literature mentionsThis unknown targets Neurofilament 200
View all literature mentionsThis polyclonal targets ANK3
View all literature mentionsThis unknown targets KCNC3 (KV3.3) Channel
View all literature mentionsThis unknown targets Pan NaV Channel
View all literature mentionsThis unknown targets KV3.1b (KCNC1) Channel
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Alexa Fluor 488
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Pan NaV Channel
View all literature mentionsThis unknown targets NaV1.6 (SCN8A) Channel
View all literature mentionsThis unknown targets Neurofilament 200
View all literature mentionsThis unknown targets SCN2A (NaV1.2) Channel
View all literature mentionsThis unknown targets KCNC3 (KV3.3) Channel
View all literature mentionsThis unknown targets KV3.1b (KCNC1) Channel
View all literature mentionsThis unknown targets KCNC3 (KV3.3) Channel
View all literature mentionsThis polyclonal targets ANK3
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Alexa Fluor 488
View all literature mentionsThis unknown targets NaV1.6 (SCN8A) Channel
View all literature mentionsThis polyclonal targets ANK3
View all literature mentionsThis polyclonal targets ANK3
View all literature mentionsThis unknown targets Neurofilament 200
View all literature mentionsThis unknown targets KV3.1b (KCNC1) Channel
View all literature mentionsThis unknown targets Pan NaV Channel
View all literature mentionsThis unknown targets SCN2A (NaV1.2) Channel
View all literature mentionsThis polyclonal targets ANK3
View all literature mentionsThis unknown targets Pan NaV Channel
View all literature mentionsThis unknown targets Neurofilament 200
View all literature mentionsThis unknown targets SCN2A (NaV1.2) Channel
View all literature mentionsThis unknown targets KCNC3 (KV3.3) Channel
View all literature mentionsThis unknown targets NaV1.6 (SCN8A) Channel
View all literature mentionsThis unknown targets KV3.1b (KCNC1) Channel
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