Searching across hundreds of databases
Multiple sclerosis (MS) is considered a chronic autoimmune disease of the central nervous system that leads to gliosis, demyelination, axonal damage and neuronal death. The MS disease aetiology is unknown, though a polymorphism of the TNFRSF1A gene, rs1800693, is known to confer an increased risk for MS. Using retroviral delivery of reprogramming transgenes, we generated six MS patient-specific iPSC lines with two distinct genotypes, CC or TT, of the polymorphism rs1800693. iPSC lines had normal karyotype, expressed pluripotency genes and differentiated into the three germ layers. These lines offer a good tool to study MS pathomechanisms and for drug testing.
Pubmed ID: 29034884 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
A supplier of various biochemical products for research in pharmacy and biotechnology as well as the specialty ingredients market. Examples of products include active pharmaceutical ingredients, stem cell therapies, drinking water sanitizers and agriculture services and products.
View all literature mentionsThis unknown targets Mouse IgM,
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgM,
View all literature mentionsThis polyclonal targets goat IgG
View all literature mentionsThis unknown targets Mouse IgM,
View all literature mentionsThis unknown targets Mouse IgG, Fc? Fragment Specific
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rat IgM,
View all literature mentionsThis unknown targets Mouse IgG, Fc? Fragment Specific
View all literature mentionsThis polyclonal targets Mouse
View all literature mentionsThis monoclonal targets Purified rabbit striated muscle actin used as immunogen
View all literature mentionsThis polyclonal targets Human HNF-3 beta / FoxA2
View all literature mentionsThis polyclonal targets Alpha-1-fetoprotein
View all literature mentionsThis monoclonal targets Actin, alpha, Smooth Muscle
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis monoclonal targets Neuronal Class III beta-Tubulin (TUJ1) Purified
View all literature mentionsThis monoclonal targets TRA-1-81 clone TRA-1-81
View all literature mentionsThis monoclonal targets HSP90B1
View all literature mentionsThis monoclonal targets Mouse Human SSEA-4 (carbohydrate from human embryonal carcinoma)
View all literature mentionsThis monoclonal targets SSEA-3 (carbohydrate from 4-8 cell mouse embryos)
View all literature mentionsThis polyclonal targets Nanog
View all literature mentionsThis monoclonal targets Oct-3/4
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
