Searching across hundreds of databases
Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor initiation remain unclear. The majority of melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melanomas can arise from melanocyte stem cells (MCSCs). Here we employ mouse models to define the role of MCSCs as melanoma cells of origin, demonstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic environmental and molecular factors required for the critical early steps of melanoma initiation. Specifically, melanomas originate from melanoma-competent MCSCs upon stimulation by UVB, which induces MCSC activation and translocation via an inflammation-dependent process. Moreover, the chromatin-remodeling factor Hmga2 in the skin plays a critical role in UVB-mediated melanomagenesis. These findings delineate melanoma formation from melanoma-competent MCSCs following extrinsic stimuli, and they suggest that abrogation of Hmga2 function in the microenvironment can suppress MCSC-originating cutaneous melanomas.
Pubmed ID: 29033353 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis polyclonal secondary targets Rat IgG (H+L)
View all literature mentionsThis monoclonal targets Tenascin C
View all literature mentionsThis unknown targets F(ab')2 Mouse IgG (H&L) Antibody Peroxidase Conjugated Pre-Adsorbed
View all literature mentionsThis unknown targets Rat IgG (H&L) Antibody Peroxidase Conjugated
View all literature mentionsThis unknown targets Rabbit IgG (H&L) Antibody Peroxidase Conjugated Pre-Adsorbed
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis monoclonal targets HMGA2 (D1A7) Rabbit mAb
View all literature mentionsThis polyclonal targets HMGA2
View all literature mentionsThis monoclonal targets Cas9
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal targets Keratin 5 Chicken Purified
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis polyclonal targets TRP2 (D-18)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Human S100 A6
View all literature mentionsThis monoclonal targets corresponding to Human SOX10 aa 400 to the C-terminus.
View all literature mentionsThis monoclonal targets Histone H2A.X, phospho (Ser139)
View all literature mentionsThis monoclonal targets Tenascin C
View all literature mentionsThis unknown targets F(ab')2 Mouse IgG (H&L) Antibody Peroxidase Conjugated Pre-Adsorbed
View all literature mentionsThis unknown targets Rabbit IgG (H&L) Antibody Peroxidase Conjugated Pre-Adsorbed
View all literature mentionsThis unknown targets Rat IgG (H&L) Antibody Peroxidase Conjugated
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis polyclonal secondary targets Rat IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis monoclonal targets HMGA2 (D1A7) Rabbit mAb
View all literature mentionsThis polyclonal targets HMGA2
View all literature mentionsThis monoclonal targets Cas9
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal targets Keratin 5 Chicken Purified
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis polyclonal targets TRP2 (D-18)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Human S100 A6
View all literature mentionsThis monoclonal targets corresponding to Human SOX10 aa 400 to the C-terminus.
View all literature mentionsThis monoclonal targets Histone H2A.X, phospho (Ser139)
View all literature mentionsThis polyclonal secondary targets Rat IgG (H+L)
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
