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Adropin is expressed in the CNS and plays a crucial role in the development of stroke. However, little is currently known about the effects of adropin on the blood-brain barrier (BBB) function after intracerebral hemorrhage (ICH). In this study, the role of adropin in collagenase-induced ICH was investigated in mice. At 1-h post-ICH, mice were administered with recombinant human adropin by intranasal. Brain water +content, BBB permeability, and neurological function were measured at different time intervals. Proteins were quantified using western blot analysis, and the localizations of adropin and Notch1 were visualized via immunofluorescence staining. It is shown that adropin reduced brain water content and improved neurological functions. Adropin preserved the functionality of BBB by increasing N-cadherin expression and reducing extravasation of albumin. Moreover, in vivo knockdown of Notch1 and Hes1 both abolished the protective effects of adropin. Taken together, our data demonstrate that adropin constitutes a potential treatment value for ICH by preserving BBB and improving functional outcomes through the Notch1 signaling pathway.
Pubmed ID: 29030969 RIS Download
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This unknown targets Antibody raised against a peptide mapping at the C-terminus of Notch 1 of human origin.
View all literature mentionsThis polyclonal targets Mouse GFAP
View all literature mentionsThis polyclonal targets Albumin
View all literature mentionsThis polyclonal targets CDH2
View all literature mentionsThis polyclonal targets claudin-5 (H-52)
View all literature mentionsThis monoclonal targets ZO-1 (R40.76)
View all literature mentionsThis polyclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis polyclonal targets activated Notch1
View all literature mentionsThis unknown targets ADROPIN
View all literature mentionsThis unknown targets Antibody raised against a peptide mapping at the C-terminus of Notch 1 of human origin.
View all literature mentionsThis polyclonal targets activated Notch1
View all literature mentionsThis unknown targets ADROPIN
View all literature mentionsThis polyclonal targets CDH2
View all literature mentionsThis polyclonal targets claudin-5 (H-52)
View all literature mentionsThis polyclonal targets Albumin
View all literature mentionsThis polyclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets ZO-1 (R40.76)
View all literature mentionsThis polyclonal targets Mouse GFAP
View all literature mentionsThis unknown targets Antibody raised against a peptide mapping at the C-terminus of Notch 1 of human origin.
View all literature mentionsThis unknown targets ADROPIN
View all literature mentionsThis polyclonal targets claudin-5 (H-52)
View all literature mentionsThis polyclonal targets CDH2
View all literature mentionsThis polyclonal targets Albumin
View all literature mentionsThis monoclonal targets ZO-1 (R40.76)
View all literature mentionsThis polyclonal targets Mouse GFAP
View all literature mentionsThis unknown targets Antibody raised against a peptide mapping at the C-terminus of Notch 1 of human origin.
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