The lung harbors its basal stem/progenitor cells (BSCs) in the protected environment of the cartilaginous airways. After major lung injuries, BSCs are activated and recruited to sites of injury. Here, we show that during homeostasis, BSCs in cartilaginous airways maintain their stem cell state by downregulating the Hippo pathway (resulting in increased nuclear Yap), which generates a localized Fgf10-expressing stromal niche; in contrast, differentiated epithelial cells in non-cartilaginous airways maintain quiescence by activating the Hippo pathway and inhibiting Fgf10 expression in airway smooth muscle cells (ASMCs). However, upon injury, surviving differentiated epithelial cells spread to maintain barrier function and recruit integrin-linked kinase to adhesion sites, which leads to Merlin degradation, downregulation of the Hippo pathway, nuclear Yap translocation, and expression and secretion of Wnt7b. Epithelial-derived Wnt7b, then in turn, induces Fgf10 expression in ASMCs, which extends the BSC niche to promote regeneration.
Pubmed ID: 29017029 RIS Download
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This polyclonal targets Chicken IgY
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View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
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View all literature mentionsThis unknown targets Chicken IgY (IgG) (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
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View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Digoxigenin
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View all literature mentionsThis polyclonal targets Human MST1 / MST2
View all literature mentionsThis polyclonal targets Human Wnt-7b
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View all literature mentionsThis monoclonal targets YAP (63.7)
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View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis unknown targets Mst1, phospho (Thr183) / Mst2, phospho (Thr180)
View all literature mentionsThis unknown targets p63
View all literature mentionsThis polyclonal targets NEW FGF10
View all literature mentionsThis unknown targets Human FGF10, C Terminus
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View all literature mentionsThis monoclonal targets Actin, alpha, Smooth Muscle
View all literature mentionsThis polyclonal targets Smad2 / 3, phospho (Ser423 / Ser425)
View all literature mentionsThis polyclonal targets BETA GALACTOSIDASE
View all literature mentionsThis unknown targets ND
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Mus musculus with name STOCK Stk4tm1.1Rjo Stk3
Mus musculus with name FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ from IMSR.
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View all literature mentionsMus musculus with name B6;129S-Sox2tm1(cre/ERT2)Hoch/J from IMSR.
View all literature mentionsThis polyclonal targets Chicken IgY
View all literature mentionsThis polyclonal targets Chicken IgY
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