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Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are transferred to glia, where they form lipid droplets (LDs). We show that glial and neuronal monocarboxylate transporters (MCTs), fatty acid transport proteins (FATPs), and apolipoproteins are critical for glial LD formation. MCTs enable glia to secrete and neurons to absorb lactate, which is converted to pyruvate and acetyl-CoA in neurons. Lactate metabolites provide a substrate for synthesis of fatty acids, which are processed and transferred to glia by FATP and apolipoproteins. In the presence of high ROS, inhibiting lactate transfer or lowering FATP or apolipoprotein levels decreases glial LD accumulation in flies and in primary mouse glial-neuronal cultures. We show that human APOE can substitute for a fly glial apolipoprotein and that APOE4, an Alzheimer's disease susceptibility allele, is impaired in lipid transport and promotes neurodegeneration, providing insights into disease mechanisms.
Pubmed ID: 28965825 RIS Download
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Vector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsCollects, maintains and distributes Drosophila melanogaster strains for research. Emphasis is placed on genetic tools that are useful to a broad range of investigations. These include basic stocks of flies used in genetic analysis such as marker, balancer, mapping, and transposon-tagging strains; mutant alleles of identified genes, including a large set of transposable element insertion alleles; defined sets of deficiencies and a variety of other chromosomal aberrations; engineered lines for somatic and germline clonal analysis; GAL4 and UAS lines for targeted gene expression; enhancer trap and lacZ-reporter strains with defined expression patterns for marking tissues; and a collection of transposon-induced lethal mutations.
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View all literature mentionsThis unknown targets CD271
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View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
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View all literature mentionsMus musculus with name C57BL/6J from IMSR.
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View all literature mentionsMus musculus with name STOCK Gt(ROSA)26Sortm1.1(CAG-cas9*.-EGFP)Fezh/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Apoetm1Unc/J from IMSR.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=lacW}Fatp1[k10307]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] kdn[A] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] Pdha[A] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] Marf[B] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] sicily[E] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=GMR-hid}SS1, y[1] w[*] P{ry[+t7.2]=neoFRT}19A; P{w[+m*]=GAL4-ey.H}SS5, P{w[+mC]=UAS-FLP.D}JD2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00039}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC04206}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC03960}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC03111}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC04895}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-SREBP.K}2/CyO; SREBP[189]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-bsk.B}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UAS-mCD8::GFP.L}LL5, P{UAS-mCD8::GFP.L}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+m*]=nSyb-GAL4.S}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+m*]=GAL4}54C from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=GAL4-elav.L}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] sicily[E] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=GMR-hid}SS1, y[1] w[*] P{ry[+t7.2]=neoFRT}19A; P{w[+m*]=GAL4-ey.H}SS5, P{w[+mC]=UAS-FLP.D}JD2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC04206}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC03960}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00039}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC03111}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMC04895}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-SREBP.K}2/CyO; SREBP[189]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-bsk.B}2 from BDSC.
View all literature mentionsMus musculus with name B6.129P2-Apoetm1Unc/J from IMSR.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=lacW}Fatp1[k10307]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] Marf[B] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] Pdha[A] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] kdn[A] P{ry[+t7.2]=neoFRT}19A/FM7c, P{w[+mC]=GAL4-Kr.C}DC1, P{w[+mC]=UAS-GFP.S65T}DC5, sn[+] from BDSC.
View all literature mentionsMus musculus with name STOCK Gt(ROSA)26Sortm1.1(CAG-cas9*.-EGFP)Fezh/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Aldh1l1-EGFP.-DTA)D8Rth/J from IMSR.
View all literature mentionsThis monoclonal targets Neuronal Class III beta-Tubulin (TUJ1) Purified
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UAS-mCD8::GFP.L}LL5, P{UAS-mCD8::GFP.L}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+m*]=nSyb-GAL4.S}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+m*]=GAL4}54C from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=GAL4-elav.L}2/CyO from BDSC.
View all literature mentionsThis monoclonal targets Human Apolipoprotein E
View all literature mentionsThis polyclonal targets Caspase-3
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View all literature mentionsThis polyclonal targets GFAP
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