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Adult newborn neurons interfere with fear discrimination in a protocol-dependent manner.

Brain and behavior | 2017

Significant enhancement of neurogenesis is known to occur in response to a variety of brain insults such as traumatic brain injury. Previous studies have demonstrated that injury-induced newborn neurons are required for hippocampus-dependent spatial learning and memory tasks like the Morris water maze, but not in contextual fear conditioning that requires both the hippocampus and amygdala. Recently, the dentate gyrus, where adult hippocampal neurogenesis occurs, has been implicated in processing information to form specific memory under specific environmental stimuli in a process known as pattern separation.

Pubmed ID: 28948089 RIS Download

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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PROX1 antibody (antibody)

RRID:AB_10712211

This polyclonal targets PROX1 antibody

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C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J (organism)

RRID:IMSR_JAX:029671

Mus musculus with name C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J from IMSR.

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PROX1 antibody (antibody)

RRID:AB_10712211

This polyclonal targets PROX1 antibody

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C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J (organism)

RRID:IMSR_JAX:029671

Mus musculus with name C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J from IMSR.

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C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J (organism)

RRID:IMSR_JAX:029671

Mus musculus with name C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J from IMSR.

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C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J (organism)

RRID:IMSR_JAX:029671

Mus musculus with name C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J from IMSR.

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PROX1 antibody (antibody)

RRID:AB_10712211

This polyclonal targets PROX1 antibody

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C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J (organism)

RRID:IMSR_JAX:029671

Mus musculus with name C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J from IMSR.

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PROX1 antibody (antibody)

RRID:AB_10712211

This polyclonal targets PROX1 antibody

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C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J (organism)

RRID:IMSR_JAX:029671

Mus musculus with name C57BL/6-Tg(Nes-TK*.-EGFP)145Sker/J from IMSR.

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