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Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Cell host & microbe | Oct 11, 2017

Diet, and specifically dietary metals, can modify the risk of infection. However, the mechanisms by which manganese (Mn), a common dietary supplement, alters infection remain unexplored. We report that dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis. Mice fed a high Mn diet display alterations in Mn levels and localization within infected tissues, and S. aureus virulence and infection of the heart are enhanced. Although the canonical mammalian Mn-sequestering protein calprotectin surrounds staphylococcal heart abscesses, calprotectin is not released into the abscess nidus and does not limit Mn in this organ. Consequently, excess Mn is bioavailable to S. aureus in the heart. Bioavailable Mn is utilized by S. aureus to detoxify reactive oxygen species and protect against neutrophil killing, enhancing fitness within the heart. Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading to fatal staphylococcal infection.

Pubmed ID: 28943329 RIS Download

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Associated grants

  • Agency: NIAID NIH HHS, Id: R01 AI069233
  • Agency: NIAID NIH HHS, Id: R21 AI107233
  • Agency: NIDDK NIH HHS, Id: T32 DK007673
  • Agency: NIGMS NIH HHS, Id: P41 GM103391
  • Agency: NIDDK NIH HHS, Id: P30 DK058404
  • Agency: NIAID NIH HHS, Id: R01 AI099394
  • Agency: NIAID NIH HHS, Id: R01 AI103268
  • Agency: NIAID NIH HHS, Id: R01 AI105129
  • Agency: NIAID NIH HHS, Id: R01 AI073843
  • Agency: NIEHS NIH HHS, Id: T32 ES007028
  • Agency: NIAID NIH HHS, Id: R01 AI101171
  • Agency: NIGMS NIH HHS, Id: T32 GM007347
  • Agency: NIAID NIH HHS, Id: HHSN272201400019C
  • Agency: NIGMS NIH HHS, Id: T32 GM065086
  • Agency: NIAID NIH HHS, Id: F32 AI120553

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