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Retinoic acid (RA) is the active ingredient of vitamin A. It exerts its canonical activity by binding to nuclear RA receptors (RARs) to regulate gene expression. Increasingly, RA is also known to elicit nongenomic RAR-independent activities, most widely detected in activating extracellular regulated kinase (ERK)1/2. This study validated the functional role of cellular retinoic acid-binding protein 1 (Crabp1) in mediating nongenomic activity in RA, specifically activating ERK1/2 to rapidly augment the cell cycle by expanding the growth 1 phase and slowing down embryonic stem cell and neural stem cell (NSC) proliferation. The study further uncovered the physiological activity of Crabp1 in modulating NSC proliferation and animal behavior. In the Crabp1 knockout mouse hippocampus, where Crabp1 is otherwise detected in the subgranular zone, neurogenesis and NSC proliferation increased and hippocampus-dependent brain functions such as learning and memory correspondingly improved. This study established the physiological role of Crabp1 in modulating stem cell proliferation and hippocampus-dependent brain activities such as learning and memory.
Pubmed ID: 28911165 RIS Download
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This monoclonal targets BrdU (3H579)
View all literature mentionsThis polyclonal targets CRABP1
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Pax-6 (AD1.5)
View all literature mentionsThis unknown targets p44 MAPK (Erk1)
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View all literature mentionsThis monoclonal targets p44 / p42 MAPK, phospho (Thr202 / Tyr204)
View all literature mentionsThis monoclonal targets Cellular Retinoic Acid Binding Protein 1
View all literature mentionsThis monoclonal targets GAPDH (6C5)
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis monoclonal targets GAPDH (6C5)
View all literature mentionsThis monoclonal targets Pax-6 (AD1.5)
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis monoclonal targets BrdU (3H579)
View all literature mentionsThis monoclonal targets Cellular Retinoic Acid Binding Protein 1
View all literature mentionsThis monoclonal targets BrdU (3H579)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Pax-6 (AD1.5)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis unknown targets p44 MAPK (Erk1)
View all literature mentionsThis monoclonal targets p44 / p42 MAPK, phospho (Thr202 / Tyr204)
View all literature mentionsThis polyclonal targets CRABP1
View all literature mentionsThis monoclonal targets Cellular Retinoic Acid Binding Protein 1
View all literature mentionsThis unknown targets p44 MAPK (Erk1)
View all literature mentionsThis monoclonal targets p44 / p42 MAPK, phospho (Thr202 / Tyr204)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis polyclonal targets CRABP1
View all literature mentionsThis monoclonal targets Pax-6 (AD1.5)
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis monoclonal targets BrdU (3H579)
View all literature mentionsThis unknown targets p44 MAPK (Erk1)
View all literature mentionsThis monoclonal targets BrdU (3H579)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Pax-6 (AD1.5)
View all literature mentionsThis monoclonal targets Cellular Retinoic Acid Binding Protein 1
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis polyclonal targets CRABP1
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets p44 / p42 MAPK, phospho (Thr202 / Tyr204)
View all literature mentionsThis polyclonal targets CRABP1
View all literature mentionsThis monoclonal targets Cellular Retinoic Acid Binding Protein 1
View all literature mentionsThis unknown targets p44 MAPK (Erk1)
View all literature mentionsThis monoclonal targets p44 / p42 MAPK, phospho (Thr202 / Tyr204)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Cellular Retinoic Acid Binding Protein 1
View all literature mentionsThis unknown targets p44 MAPK (Erk1)
View all literature mentionsThis monoclonal targets p44 / p42 MAPK, phospho (Thr202 / Tyr204)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis polyclonal targets CRABP1
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