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Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.

eLife | Sep 12, 2017

MyD88 is the main adaptor molecule for TLR and IL-1R family members. Here, we demonstrated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis and expression of activation/memory genes during infection with the intracellular parasite Trypanosoma cruzi, as evidenced by transcriptome and cytometry analyses in mixed bone-marrow (BM) chimeras. The lack of direct IL-18R signaling in T cells, but not of IL-1R, phenocopied the absence of the MyD88 pathway, indicating that IL-18R is a critical MyD88-upstream pathway involved in the establishment of the Th1 response against an in vivo infection, a presently controvert subject. Accordingly, Il18r1-/- mice display lower levels of Th1 cells and are highly susceptible to infection, but can be rescued from mortality by the adoptive transfer of WT CD4+ T cells. Our findings establish the T-cell intrinsic IL-18R/MyD88 pathway as a crucial element for induction of cognate Th1 responses against an important human pathogen.

Pubmed ID: 28895840 RIS Download

Mesh terms: Adoptive Transfer | Animals | Chagas Disease | Disease Models, Animal | Flow Cytometry | Gene Expression Profiling | Interleukin-18 Receptor alpha Subunit | Mice, Inbred C57BL | Mice, Knockout | Myeloid Differentiation Factor 88 | Signal Transduction | Survival Analysis | Th1 Cells | Trypanosoma cruzi

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