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CD4+ follicular helper T (Tfh) cells have been shown to be critical for the activation of germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection activates both GC as well as non-GC B cell responses. Here, we sought to explore whether Tfh cells and GC B cells are required to eliminate a Plasmodium infection. A CD4 T cell-targeted deletion of the gene that encodes Bcl6, the master transcription factor for the Tfh program, resulted in complete disruption of the Tfh response to Plasmodium chabaudi in C57BL/6 mice and consequent disruption of GC responses and IgG responses and the inability to eliminate the otherwise self-resolving chronic P. chabaudi infection. On the other hand, and contrary to previous observations in immunization and viral infection models, Signaling Lymphocyte Activation Molecule (SLAM)-Associated Protein (SAP)-deficient mice were able to activate Tfh cells, GC B cells, and IgG responses to the parasite. This study demonstrates the critical role for Tfh cells in controlling this systemic infection, and highlights differences in the signals required to activate GC B cell responses to this complex parasite compared with those of protein immunizations and viral infections. Therefore, these data are highly pertinent for designing malaria vaccines able to activate broadly protective B-cell responses.
Pubmed ID: 28888925 RIS Download
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View all literature mentionsCommercial antibody supplier and developer for biomedical research. These products are compatible with use in flow cytometry and mass cytometry, immunoprecipitation and chip, western blotting, immunofluorescence microscopy, and quantitative multiplexing.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets CD3G antibody [EPR4516]
View all literature mentionsThis monoclonal targets A suspension of Abelson murine leukemia virus-induced pre-B tumor cells.
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets GL7
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted, Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets CD3G antibody [EPR4516]
View all literature mentionsThis monoclonal targets A suspension of Abelson murine leukemia virus-induced pre-B tumor cells.
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets GL7
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted, Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis monoclonal targets A suspension of Abelson murine leukemia virus-induced pre-B tumor cells.
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets GL7
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD3G antibody [EPR4516]
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted, Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
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